Alteration of c-fos gene methylation in human gliomas

Shinji Uyeno, Jun Ichiro Komura, Riichi Tawa, Yasuhiro Aoki, Masayuki Nata, Hironobu Sasano, Hiroshi Nakura, Kaoru Sagisaka, Hiromu Sakurai, Takamasa Kayama, Takashi Yoshimoto, Tetsuya Ono

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

In an attempt to find a common DNA alteration occurring in human glioma, we examined DNA methylation in 34 gliomas of various pathological grades and compared them with those in normal cerebral subcortex DNA. The total methylated cytosine levels in the genome did not differ appreciably between the tumors and the normal tissues; however, the degree of DNA methylation in several proto-oncogenes and suppressor oncogenes showed some alterations. Among them, the c-fos gene demonstrated deviation from that of normal tissues in all cases examined, suggesting that the alteration of c-fos gene methylation plays a role in the early steps of human glioma development.

Original languageEnglish
Pages (from-to)91-100
Number of pages10
JournalMolecular Carcinogenesis
Volume16
Issue number2
DOIs
Publication statusPublished - 1996 Jun

Keywords

  • DNA methylation
  • Human glioma
  • Proto-oncogene
  • Suppressor oncogene
  • c-fos

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research

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