Alteration of c-fos gene methylation in human gliomas

Shinji Uyeno; Jun Ichiro Komura; Riichi Tawa; Yasuhiro Aoki; Masayuki Nata; Hironobu Sasano; Hiroshi Nakura; Kaoru Sagisaka; Hiromu Sakurai; Takamasa Kayama; Takashi Yoshimoto; Tetsuya Ono

doi:10.1002/(SICI)1098-2744(199606)16:2<91::AID-MC5>3.0.CO;2-Q

Alteration of c-fos gene methylation in human gliomas

Shinji Uyeno, Jun Ichiro Komura, Riichi Tawa, Yasuhiro Aoki, Masayuki Nata, Hironobu Sasano, Hiroshi Nakura, Kaoru Sagisaka, Hiromu Sakurai, Takamasa Kayama, Takashi Yoshimoto, Tetsuya Ono

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

In an attempt to find a common DNA alteration occurring in human glioma, we examined DNA methylation in 34 gliomas of various pathological grades and compared them with those in normal cerebral subcortex DNA. The total methylated cytosine levels in the genome did not differ appreciably between the tumors and the normal tissues; however, the degree of DNA methylation in several proto-oncogenes and suppressor oncogenes showed some alterations. Among them, the c-fos gene demonstrated deviation from that of normal tissues in all cases examined, suggesting that the alteration of c-fos gene methylation plays a role in the early steps of human glioma development.

Original language	English
Pages (from-to)	91-100
Number of pages	10
Journal	Molecular Carcinogenesis
Volume	16
Issue number	2
DOIs	https://doi.org/10.1002/(SICI)1098-2744(199606)16:2<91::AID-MC5>3.0.CO;2-Q
Publication status	Published - 1996 Jun

Keywords

DNA methylation
Human glioma
Proto-oncogene
Suppressor oncogene
c-fos

ASJC Scopus subject areas

Molecular Biology
Cancer Research

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Alteration of c-fos gene methylation in human gliomas. / Uyeno, Shinji; Komura, Jun Ichiro; Tawa, Riichi; Aoki, Yasuhiro; Nata, Masayuki; Sasano, Hironobu; Nakura, Hiroshi; Sagisaka, Kaoru; Sakurai, Hiromu; Kayama, Takamasa; Yoshimoto, Takashi; Ono, Tetsuya.

In: Molecular Carcinogenesis, Vol. 16, No. 2, 06.1996, p. 91-100.

Research output: Contribution to journal › Article › peer-review

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AU - Sasano, Hironobu

AU - Nakura, Hiroshi

AU - Sagisaka, Kaoru

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AU - Kayama, Takamasa

AU - Yoshimoto, Takashi

AU - Ono, Tetsuya

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