Alteration of c-fos gene methylation in human gliomas

Shinji Uyeno; Jun Ichiro Komura; Riichi Tawa; Yasuhiro Aoki; Masayuki Nata; Hironobu Sasano; Hiroshi Nakura; Kaoru Sagisaka; Hiromu Sakurai; Takamasa Kayama; Takashi Yoshimoto; Tetsuya Ono

doi:10.1002/(SICI)1098-2744(199606)16:2<91::AID-MC5>3.0.CO;2-Q

Alteration of c-fos gene methylation in human gliomas

Shinji Uyeno, Jun Ichiro Komura, Riichi Tawa, Yasuhiro Aoki, Masayuki Nata, Hironobu Sasano, Hiroshi Nakura, Kaoru Sagisaka, Hiromu Sakurai, Takamasa Kayama, Takashi Yoshimoto, Tetsuya Ono

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

In an attempt to find a common DNA alteration occurring in human glioma, we examined DNA methylation in 34 gliomas of various pathological grades and compared them with those in normal cerebral subcortex DNA. The total methylated cytosine levels in the genome did not differ appreciably between the tumors and the normal tissues; however, the degree of DNA methylation in several proto-oncogenes and suppressor oncogenes showed some alterations. Among them, the c-fos gene demonstrated deviation from that of normal tissues in all cases examined, suggesting that the alteration of c-fos gene methylation plays a role in the early steps of human glioma development.

Original language	English
Pages (from-to)	91-100
Number of pages	10
Journal	Molecular Carcinogenesis
Volume	16
Issue number	2
DOIs	https://doi.org/10.1002/(SICI)1098-2744(199606)16:2<91::AID-MC5>3.0.CO;2-Q
Publication status	Published - 1996 Jun

Keywords

DNA methylation
Human glioma
Proto-oncogene
Suppressor oncogene
c-fos

ASJC Scopus subject areas

Molecular Biology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/(SICI)1098-2744(199606)16:2<91::AID-MC5>3.0.CO;2-Q

Cite this

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title = "Alteration of c-fos gene methylation in human gliomas",

abstract = "In an attempt to find a common DNA alteration occurring in human glioma, we examined DNA methylation in 34 gliomas of various pathological grades and compared them with those in normal cerebral subcortex DNA. The total methylated cytosine levels in the genome did not differ appreciably between the tumors and the normal tissues; however, the degree of DNA methylation in several proto-oncogenes and suppressor oncogenes showed some alterations. Among them, the c-fos gene demonstrated deviation from that of normal tissues in all cases examined, suggesting that the alteration of c-fos gene methylation plays a role in the early steps of human glioma development.",

keywords = "DNA methylation, Human glioma, Proto-oncogene, Suppressor oncogene, c-fos",

author = "Shinji Uyeno and Komura, {Jun Ichiro} and Riichi Tawa and Yasuhiro Aoki and Masayuki Nata and Hironobu Sasano and Hiroshi Nakura and Kaoru Sagisaka and Hiromu Sakurai and Takamasa Kayama and Takashi Yoshimoto and Tetsuya Ono",

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T1 - Alteration of c-fos gene methylation in human gliomas

AU - Uyeno, Shinji

AU - Komura, Jun Ichiro

AU - Tawa, Riichi

AU - Aoki, Yasuhiro

AU - Nata, Masayuki

AU - Sasano, Hironobu

AU - Nakura, Hiroshi

AU - Sagisaka, Kaoru

AU - Sakurai, Hiromu

AU - Kayama, Takamasa

AU - Yoshimoto, Takashi

AU - Ono, Tetsuya

PY - 1996/6

Y1 - 1996/6

N2 - In an attempt to find a common DNA alteration occurring in human glioma, we examined DNA methylation in 34 gliomas of various pathological grades and compared them with those in normal cerebral subcortex DNA. The total methylated cytosine levels in the genome did not differ appreciably between the tumors and the normal tissues; however, the degree of DNA methylation in several proto-oncogenes and suppressor oncogenes showed some alterations. Among them, the c-fos gene demonstrated deviation from that of normal tissues in all cases examined, suggesting that the alteration of c-fos gene methylation plays a role in the early steps of human glioma development.

AB - In an attempt to find a common DNA alteration occurring in human glioma, we examined DNA methylation in 34 gliomas of various pathological grades and compared them with those in normal cerebral subcortex DNA. The total methylated cytosine levels in the genome did not differ appreciably between the tumors and the normal tissues; however, the degree of DNA methylation in several proto-oncogenes and suppressor oncogenes showed some alterations. Among them, the c-fos gene demonstrated deviation from that of normal tissues in all cases examined, suggesting that the alteration of c-fos gene methylation plays a role in the early steps of human glioma development.

KW - DNA methylation

KW - Human glioma

KW - Proto-oncogene

KW - Suppressor oncogene

KW - c-fos

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IS - 2

ER -

Alteration of c-fos gene methylation in human gliomas

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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