Abstract
In an attempt to find a common DNA alteration occurring in human glioma, we examined DNA methylation in 34 gliomas of various pathological grades and compared them with those in normal cerebral subcortex DNA. The total methylated cytosine levels in the genome did not differ appreciably between the tumors and the normal tissues; however, the degree of DNA methylation in several proto-oncogenes and suppressor oncogenes showed some alterations. Among them, the c-fos gene demonstrated deviation from that of normal tissues in all cases examined, suggesting that the alteration of c-fos gene methylation plays a role in the early steps of human glioma development.
Original language | English |
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Pages (from-to) | 91-100 |
Number of pages | 10 |
Journal | Molecular Carcinogenesis |
Volume | 16 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1996 Jun |
Keywords
- DNA methylation
- Human glioma
- Proto-oncogene
- Suppressor oncogene
- c-fos
ASJC Scopus subject areas
- Molecular Biology
- Cancer Research