Allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome in adolescent and young adult patients

Yoshimitsu Shimomura, Masahiko Hara, Takaaki Konuma, Hidehiro Itonaga, Noriko Doki, Yukiyasu Ozawa, Tetsuya Eto, Naoyuki Uchida, Jun Aoki, Jun Kato, Yasushi Onishi, Satoshi Takahashi, Kentaro Fukushima, Hirohisa Nakamae, Toshiro Kawakita, Junji Tanaka, Takahiro Fukuda, Yoshiko Atsuta, Takayuki Ishikawa, Ken Ishiyama

Research output: Contribution to journalArticlepeer-review

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curable treatment option for adolescent and young adult (AYA) patients with myelodysplastic syndrome (MDS). The study aim was to evaluate epidemiological data and identify prognostic factors for AYA patients with MDS undergoing allogeneic HSCT. Here, 645 patients were selected from patients enrolled in a multicenter prospective registry for HSCT from 2000 to 2015. The primary endpoint was 3-year overall survival (OS). Survival rates were estimated using the Kaplan–Meier method. Prognostic factors were identified using the multivariable Cox proportional hazards model. The 3-year OS was 71.2% (95% confidence interval [CI]: 67.4–74.6%). In multivariable analysis, active disease status (adjusted hazard ratio: 1.54, 95% CI: 1.09–2.18, p = 0.016), poor cytogenetic risk (1.62, 1.12–2.36, p = 0.011), poor performance status (2.01, 1.13–3.56, p = 0.016), human leukocyte antigen (HLA)-matched unrelated donors (2.23, 1.39–3.59, p < 0.001), HLA-mismatched unrelated donors (2.16, 1.09–4.28, p = 0.027), and cord blood transplantation (2.44, 1.43–4.17, p = 0.001) were significantly associated with poor 3-year OS. In conclusion, in AYA patients with MDS the 3-year OS following allogeneic HSCT was 71.2%. Active disease status, poor cytogenetic risk, poor performance status, and donor sources other than related donors were associated with poor 3-year OS.

Original languageEnglish
Pages (from-to)2510-2517
Number of pages8
JournalBone Marrow Transplantation
Volume56
Issue number10
DOIs
Publication statusPublished - 2021 Oct

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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