Allogeneic Hematopoietic Stem Cell Transplantation for Leukocyte Adhesion Deficiency

Yasuo Horikoshi, Katsutsugu Umeda, Kohsuke Imai, Hiromasa Yabe, Yoji Sasahara, Kenichiro Watanabe, Yukiyasu Ozawa, Yoshiko Hashii, Hidemitsu Kurosawa, Shigeaki Nonoyama, Tomohiro Morio

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Abstract

The clinical outcome of allogeneic hematopoietic stem cell transplantation (HSCT) was retrospectively analyzed in 6 patients with leukocyte adhesion deficiency. Of 3 patients transplanted with myeloablative conditioning, 2 patients had complete chimerism and 1 patient had mixed chimerism. By contrast, all 3 patients transplanted with reduced-intensity conditioning (RIC) had mixed chimerism, one of whom progressed to secondary graft failure. All patients with low-level mixed chimerism and secondary graft failure were rescued by donor lymphocyte infusion or a second HSCT. RIC-HSCT is feasible for leukocyte adhesion deficiency, although further refinement/modification of conditioning is required to achieve higher donor chimerism levels.

Original languageEnglish
Pages (from-to)137-140
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume40
Issue number2
DOIs
Publication statusPublished - 2018 Jan 1

Keywords

  • donor lymphocyte infusion
  • hematopoietic stem cell transplantation
  • leukocyte adhesion deficiency
  • reduced-intensity conditioning

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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  • Cite this

    Horikoshi, Y., Umeda, K., Imai, K., Yabe, H., Sasahara, Y., Watanabe, K., Ozawa, Y., Hashii, Y., Kurosawa, H., Nonoyama, S., & Morio, T. (2018). Allogeneic Hematopoietic Stem Cell Transplantation for Leukocyte Adhesion Deficiency. Journal of Pediatric Hematology/Oncology, 40(2), 137-140. https://doi.org/10.1097/MPH.0000000000001028