Alleviation of fatty liver by α-linolenic acid

Yohanes Buang, Jae Young Cha, Koji Nagao, Yu Ming Wang, Nao Inoue, Teruyoshi Yanagita

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


We compared the efficacy of alpha-linolenic acid (α-LNA, n-3) and linoleic acid (LA, n-6) on orotic acid (OA)-induced fatty liver in Sprague-Dawley rats. Rats were fed semi-synthetic diets containing either LA or α-LNA with or without 1% OA for 2 wk. OA supplementation lowered serum lipids in LA+OA groups. In addition to the decline of serum lipids in α-LNA groups compared to LA groups, a further decrease was found in α-LNA+OA groups compared to LA+OA groups. OA-containing diets significantly increased the liver weights and triacylglycerol (TG) accumulations compared with the OA-free diets. These results were attributed to the significant increases in the activities of phosphatidate phosphohydrolase (PAP), a rate-limiting enzyme of TG synthesis, and glucose-6-phosphate dehydrogenase, a fatty acid synthesis-related enzyme. However, the increase of PAP activity was significantly less in the α-LNA+OA group as compared with the LA+OA group. These results suggest that dietary α-LNA alleviates OA-induced hepatic TG accumulation through the attenuation of hepatic TG synthesis in rats.

Original languageEnglish
Pages (from-to)272-276
Number of pages5
JournalJournal of nutritional science and vitaminology
Issue number4
Publication statusPublished - 2004 Aug
Externally publishedYes


  • Fatty liver
  • Orotic acid
  • Phosphatidate phosphohydrolase
  • Triacylglycerol
  • α-linolenic acid

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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