Abstract
We compared the efficacy of alpha-linolenic acid (α-LNA, n-3) and linoleic acid (LA, n-6) on orotic acid (OA)-induced fatty liver in Sprague-Dawley rats. Rats were fed semi-synthetic diets containing either LA or α-LNA with or without 1% OA for 2 wk. OA supplementation lowered serum lipids in LA+OA groups. In addition to the decline of serum lipids in α-LNA groups compared to LA groups, a further decrease was found in α-LNA+OA groups compared to LA+OA groups. OA-containing diets significantly increased the liver weights and triacylglycerol (TG) accumulations compared with the OA-free diets. These results were attributed to the significant increases in the activities of phosphatidate phosphohydrolase (PAP), a rate-limiting enzyme of TG synthesis, and glucose-6-phosphate dehydrogenase, a fatty acid synthesis-related enzyme. However, the increase of PAP activity was significantly less in the α-LNA+OA group as compared with the LA+OA group. These results suggest that dietary α-LNA alleviates OA-induced hepatic TG accumulation through the attenuation of hepatic TG synthesis in rats.
Original language | English |
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Pages (from-to) | 272-276 |
Number of pages | 5 |
Journal | Journal of nutritional science and vitaminology |
Volume | 50 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2004 Aug |
Externally published | Yes |
Keywords
- Fatty liver
- Orotic acid
- Phosphatidate phosphohydrolase
- Triacylglycerol
- α-linolenic acid
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics