Allergic airway response and potassium channels: Histamine release and airway inflammation

M. Ichinose, M. Miura, T. Takahashi, H. Yamauchi, N. Kageyama, M. Tomaki, N. Endoh, E. Sakurai, T. Watanabe, K. Shirato

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The possible involvement of potassium (K) channels in allergic airway responses was examined in ovalbumin (OA)-sensitized guinea pigs. An ATP-sensitive K channel opener (BRL-38227) inhibited OA inhalation-induced bronchoconstriction and airway plasma leakage. BRL-38227 also had an inhibitory effect on exogenous histamine- and leukotriene-induced responses. In contrast, BRL-38227 did not affect OA-induced histamine release from minced lung tissues. Therefore, the ATP-sensitive K channel opener inhibits allergic bronchoconstriction and plasma leakage as a result of its effect on airway smooth muscle and postcapillary venules. Apamin, a small conductance Ca2+-activated K channel (P(K,Ca)) blocker, significantly inhibited both OA-induced tracheal contraction and histamine release from lung tissues, suggesting that this compound reduces allergic airway responses via a mast cell stabilizing effect. We conclude that ATP-sensitive K channel opening and small conductance P(K,Ca) closure may be beneficial for preventing allergic airway responses.

Original languageEnglish
Pages (from-to)36-39
Number of pages4
JournalMethods and Findings in Experimental and Clinical Pharmacology
Volume17
Issue numberSUPPL. C
Publication statusPublished - 1995

Keywords

  • asthma
  • bronchoconstriction
  • histamine
  • plasma leakage

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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    Ichinose, M., Miura, M., Takahashi, T., Yamauchi, H., Kageyama, N., Tomaki, M., Endoh, N., Sakurai, E., Watanabe, T., & Shirato, K. (1995). Allergic airway response and potassium channels: Histamine release and airway inflammation. Methods and Findings in Experimental and Clinical Pharmacology, 17(SUPPL. C), 36-39.