Abstract
We analyzed apolipoprotein E (apo E) genotypes in 53 Japanese sporadic Creutzfeldt-Jakob disease (CJD) patients and 100 normal controls using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. The apo E allelic frequencies in Japanese sporadic CJD patients and our control population were as follows: ε{lunate}2, 6.6% versus 7.5%; ε{lunate}3, 82.1% versus 81.5%; ε{lunate}4, 11.3% versus 11.0%. The mean ages at onset in Japanese sporadic CJD patients were as follows: ε{lunate}3/ε{lunate}3, 66.8 years; ε{lunate}3/ε{lunate}4, 66.3 years; ε{lunate}2/ε{lunate}3, 68.6 years. These results indicate that there is no association between apo E genotype and sporadic CJD in Japan.
Original language | English |
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Pages (from-to) | 209-211 |
Number of pages | 3 |
Journal | Neuroscience Letters |
Volume | 187 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1995 Mar 10 |
Externally published | Yes |
Keywords
- Age at onset
- Apolipoprotein E
- Creutzfeldt-Jakob disease
- Genotype distribution
- Polymerase chain reaction
- Restriction fragment length polymorphism
ASJC Scopus subject areas
- Neuroscience(all)