Allelic variation of apolipoprotein E in Japanese sporadic Creutzfeldt-Jakob disease patients

Yasushi Nakagawa, Tetsuyuki Kitamoto, Hisako Furukawa, Koji Ogomori, Jun Tateishi

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

We analyzed apolipoprotein E (apo E) genotypes in 53 Japanese sporadic Creutzfeldt-Jakob disease (CJD) patients and 100 normal controls using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. The apo E allelic frequencies in Japanese sporadic CJD patients and our control population were as follows: ε{lunate}2, 6.6% versus 7.5%; ε{lunate}3, 82.1% versus 81.5%; ε{lunate}4, 11.3% versus 11.0%. The mean ages at onset in Japanese sporadic CJD patients were as follows: ε{lunate}3/ε{lunate}3, 66.8 years; ε{lunate}3/ε{lunate}4, 66.3 years; ε{lunate}2/ε{lunate}3, 68.6 years. These results indicate that there is no association between apo E genotype and sporadic CJD in Japan.

Original languageEnglish
Pages (from-to)209-211
Number of pages3
JournalNeuroscience Letters
Volume187
Issue number3
DOIs
Publication statusPublished - 1995 Mar 10
Externally publishedYes

Keywords

  • Age at onset
  • Apolipoprotein E
  • Creutzfeldt-Jakob disease
  • Genotype distribution
  • Polymerase chain reaction
  • Restriction fragment length polymorphism

ASJC Scopus subject areas

  • Neuroscience(all)

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