Allelic variation of apolipoprotein E in Japanese sporadic Creutzfeldt-Jakob disease patients

Yasushi Nakagawa; Tetsuyuki Kitamoto; Hisako Furukawa; Koji Ogomori; Jun Tateishi

doi:10.1016/0304-3940(95)11366-5

Allelic variation of apolipoprotein E in Japanese sporadic Creutzfeldt-Jakob disease patients

Yasushi Nakagawa, Tetsuyuki Kitamoto, Hisako Furukawa, Koji Ogomori, Jun Tateishi

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

We analyzed apolipoprotein E (apo E) genotypes in 53 Japanese sporadic Creutzfeldt-Jakob disease (CJD) patients and 100 normal controls using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. The apo E allelic frequencies in Japanese sporadic CJD patients and our control population were as follows: ε{lunate}2, 6.6% versus 7.5%; ε{lunate}3, 82.1% versus 81.5%; ε{lunate}4, 11.3% versus 11.0%. The mean ages at onset in Japanese sporadic CJD patients were as follows: ε{lunate}3/ε{lunate}3, 66.8 years; ε{lunate}3/ε{lunate}4, 66.3 years; ε{lunate}2/ε{lunate}3, 68.6 years. These results indicate that there is no association between apo E genotype and sporadic CJD in Japan.

Original language	English
Pages (from-to)	209-211
Number of pages	3
Journal	Neuroscience Letters
Volume	187
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(95)11366-5
Publication status	Published - 1995 Mar 10
Externally published	Yes

Keywords

Age at onset
Apolipoprotein E
Creutzfeldt-Jakob disease
Genotype distribution
Polymerase chain reaction
Restriction fragment length polymorphism

ASJC Scopus subject areas

Neuroscience(all)

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@article{74599357f49b4a9398bf921f8ee90bd8,

title = "Allelic variation of apolipoprotein E in Japanese sporadic Creutzfeldt-Jakob disease patients",

abstract = "We analyzed apolipoprotein E (apo E) genotypes in 53 Japanese sporadic Creutzfeldt-Jakob disease (CJD) patients and 100 normal controls using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. The apo E allelic frequencies in Japanese sporadic CJD patients and our control population were as follows: ε{lunate}2, 6.6% versus 7.5%; ε{lunate}3, 82.1% versus 81.5%; ε{lunate}4, 11.3% versus 11.0%. The mean ages at onset in Japanese sporadic CJD patients were as follows: ε{lunate}3/ε{lunate}3, 66.8 years; ε{lunate}3/ε{lunate}4, 66.3 years; ε{lunate}2/ε{lunate}3, 68.6 years. These results indicate that there is no association between apo E genotype and sporadic CJD in Japan.",

keywords = "Age at onset, Apolipoprotein E, Creutzfeldt-Jakob disease, Genotype distribution, Polymerase chain reaction, Restriction fragment length polymorphism",

author = "Yasushi Nakagawa and Tetsuyuki Kitamoto and Hisako Furukawa and Koji Ogomori and Jun Tateishi",

year = "1995",

month = mar,

day = "10",

doi = "10.1016/0304-3940(95)11366-5",

language = "English",

volume = "187",

pages = "209--211",

journal = "Neuroscience Letters",

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TY - JOUR

T1 - Allelic variation of apolipoprotein E in Japanese sporadic Creutzfeldt-Jakob disease patients

AU - Nakagawa, Yasushi

AU - Kitamoto, Tetsuyuki

AU - Furukawa, Hisako

AU - Ogomori, Koji

AU - Tateishi, Jun

PY - 1995/3/10

Y1 - 1995/3/10

N2 - We analyzed apolipoprotein E (apo E) genotypes in 53 Japanese sporadic Creutzfeldt-Jakob disease (CJD) patients and 100 normal controls using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. The apo E allelic frequencies in Japanese sporadic CJD patients and our control population were as follows: ε{lunate}2, 6.6% versus 7.5%; ε{lunate}3, 82.1% versus 81.5%; ε{lunate}4, 11.3% versus 11.0%. The mean ages at onset in Japanese sporadic CJD patients were as follows: ε{lunate}3/ε{lunate}3, 66.8 years; ε{lunate}3/ε{lunate}4, 66.3 years; ε{lunate}2/ε{lunate}3, 68.6 years. These results indicate that there is no association between apo E genotype and sporadic CJD in Japan.

AB - We analyzed apolipoprotein E (apo E) genotypes in 53 Japanese sporadic Creutzfeldt-Jakob disease (CJD) patients and 100 normal controls using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. The apo E allelic frequencies in Japanese sporadic CJD patients and our control population were as follows: ε{lunate}2, 6.6% versus 7.5%; ε{lunate}3, 82.1% versus 81.5%; ε{lunate}4, 11.3% versus 11.0%. The mean ages at onset in Japanese sporadic CJD patients were as follows: ε{lunate}3/ε{lunate}3, 66.8 years; ε{lunate}3/ε{lunate}4, 66.3 years; ε{lunate}2/ε{lunate}3, 68.6 years. These results indicate that there is no association between apo E genotype and sporadic CJD in Japan.

KW - Age at onset

KW - Apolipoprotein E

KW - Creutzfeldt-Jakob disease

KW - Genotype distribution

KW - Polymerase chain reaction

KW - Restriction fragment length polymorphism

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