TY - JOUR
T1 - Allelic loss on 17p13 (TP53) and allelic loss on 3p21 in early squamous cell carcinoma of the lung
AU - Endo, Chiaki
AU - Sato, Masami
AU - Fujimura, Shigefumi
AU - Sakurada, Akira
AU - Aikawa, Hirokazu
AU - Takahashi, Satomi
AU - Usuda, Katsuo
AU - Saito, Yasuki
AU - Sagawa, Motoyasu
PY - 2000
Y1 - 2000
N2 - Roentgenographically occult bronchogenic squamous cell carcinomas are early lung cancers that localize in the bronchial wall, and are thought to be a good model to elucidate the carcinogenesis of lung cancer. In the present study, we analyzed the incidence of allelic losses on chromosome regions 3p21 and 17p13 in 40 cases of roentgenographically occult bronchogenic squamous cell carcinomas, using three microsatellite dinucleotide polymorphic markers. We also investigated the relationship between such allelic loss and the clinicopathological findings of those cases. These chromosome regions showed frequent losses. Moreover, the incidence of loss on 17p13 increased gradually along with the advance of the depth of invasion, while the incidence of loss on 3p21 increased along with the advancing length of the longitudinal extension. These results suggested that these chromosome regions play different roles in lung cancer progression, i.e., the 3p21 chromosome region was related to the longitudinal extension of the carcinoma while the 17p13 (p53) region was related to the depth of invasion.
AB - Roentgenographically occult bronchogenic squamous cell carcinomas are early lung cancers that localize in the bronchial wall, and are thought to be a good model to elucidate the carcinogenesis of lung cancer. In the present study, we analyzed the incidence of allelic losses on chromosome regions 3p21 and 17p13 in 40 cases of roentgenographically occult bronchogenic squamous cell carcinomas, using three microsatellite dinucleotide polymorphic markers. We also investigated the relationship between such allelic loss and the clinicopathological findings of those cases. These chromosome regions showed frequent losses. Moreover, the incidence of loss on 17p13 increased gradually along with the advance of the depth of invasion, while the incidence of loss on 3p21 increased along with the advancing length of the longitudinal extension. These results suggested that these chromosome regions play different roles in lung cancer progression, i.e., the 3p21 chromosome region was related to the longitudinal extension of the carcinoma while the 17p13 (p53) region was related to the depth of invasion.
KW - Depth of invasion
KW - Heterozygosity
KW - Longitudinal extension
KW - Roentgenographically occult lung cancer
KW - Squamous cell carcinoma
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U2 - 10.1007/s005950070079
DO - 10.1007/s005950070079
M3 - Article
C2 - 10955731
AN - SCOPUS:0033839406
VL - 30
SP - 695
EP - 699
JO - Surgery Today
JF - Surgery Today
SN - 0941-1291
IS - 8
ER -