Allelic loss of DNA locus of the RET proto-oncogene in small cell lung cancer

Hitoyasu Futami, Shin Ichi Egawa, Kayo Takasaki, Toshihiko Tsukada, Masahiko Shiraishi, Ken Yamaguchi

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

We analyzed all 21 exons of the RET proto-oncogene of paired genomic DNA from tumors and normal tissues in 12 small cell lung cancer (SCLC) patients for the presence of genetic alteration. Polymerase chain reaction single-strand conformation polymorphism analysis and direct sequencing revealed that heterozygosity of the RET proto-oncogene was lost in the tumor tissues of six patients out of eight informative SCLC patients, although point mutation was not evident in any tumors. These results suggest that a deletion of the chromosomal region including the RET proto-oncogene is involved in the pathogenesis of SCLC.

Original languageEnglish
Pages (from-to)59-65
Number of pages7
JournalCancer Letters
Volume195
Issue number1
DOIs
Publication statusPublished - 2003 May 30
Externally publishedYes

Keywords

  • Loss of heterozygosity
  • RET
  • Small cell lung cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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