Allele-specific expression analysis of PEG1/MEST in head and neck squamous cell carcinomas

Hideyuki Kataoka; Seiji Nakano; Yasuomi Kunimoto; Naoko Sugie; Mitsuhiko Osaki; Narikazu Uzawa; Mitsuaki A. Yoshida; Mitsuo Oshimura; Hiroya Kitano

Allele-specific expression analysis of PEG1/MEST in head and neck squamous cell carcinomas

Hideyuki Kataoka, Seiji Nakano, Yasuomi Kunimoto, Naoko Sugie, Mitsuhiko Osaki, Narikazu Uzawa, Mitsuaki A. Yoshida, Mitsuo Oshimura, Hiroya Kitano

MED - United Centers for Advanced Research and Translational Medicine (ART)

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Abstract

Genomic imprinting is an epigenetic feature that plays a significant role in carcinogenesis. In this study, we examined the expression status of an imprinted gene, paternally expressed gene 1/mesoderm-specific transcript (PEG1/MEST), in 38 cases of head and neck squamous cell carcinomas (HNSCCs) and in 17 oral squamous cancer cell lines. Loss of imprinting (LOI) of PEG1/MEST was found in 8 of 10 (80%) in tumor specimens, and 6 of 10 (60%) informative cases even in the extracted normal tissue specimens. As for the oral squamous cancer cell lines, LOI was detected in 5 of 8 (62.5%) informative cases in PEG1/MEST. Thus, these data showed that abnormal expression of PEG1/MEST was found at a high frequency in the tumor, the extracted normal tissue specimens and the oral squamous cancer cell lines. PEG1/MEST LOI in extracted normal tissue specimens may have a potential individual cancer risk for HNSCC.

Original language	English
Pages (from-to)	85-90
Number of pages	6
Journal	Yonago Acta Medica
Volume	52
Issue number	2
Publication status	Published - 2009 Jun 1

Keywords

Head and neck squamous cell carcinoma
Loss of imprinting
PEG1/MEST

ASJC Scopus subject areas

Medicine(all)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Allele-specific expression analysis of PEG1/MEST in head and neck squamous cell carcinomas. / Kataoka, Hideyuki; Nakano, Seiji; Kunimoto, Yasuomi; Sugie, Naoko; Osaki, Mitsuhiko; Uzawa, Narikazu; Yoshida, Mitsuaki A.; Oshimura, Mitsuo; Kitano, Hiroya.

In: Yonago Acta Medica, Vol. 52, No. 2, 01.06.2009, p. 85-90.

Research output: Contribution to journal › Article › peer-review

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abstract = "Genomic imprinting is an epigenetic feature that plays a significant role in carcinogenesis. In this study, we examined the expression status of an imprinted gene, paternally expressed gene 1/mesoderm-specific transcript (PEG1/MEST), in 38 cases of head and neck squamous cell carcinomas (HNSCCs) and in 17 oral squamous cancer cell lines. Loss of imprinting (LOI) of PEG1/MEST was found in 8 of 10 (80%) in tumor specimens, and 6 of 10 (60%) informative cases even in the extracted normal tissue specimens. As for the oral squamous cancer cell lines, LOI was detected in 5 of 8 (62.5%) informative cases in PEG1/MEST. Thus, these data showed that abnormal expression of PEG1/MEST was found at a high frequency in the tumor, the extracted normal tissue specimens and the oral squamous cancer cell lines. PEG1/MEST LOI in extracted normal tissue specimens may have a potential individual cancer risk for HNSCC.",

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AU - Kunimoto, Yasuomi

AU - Sugie, Naoko

AU - Osaki, Mitsuhiko

AU - Uzawa, Narikazu

AU - Yoshida, Mitsuaki A.

AU - Oshimura, Mitsuo

AU - Kitano, Hiroya

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N2 - Genomic imprinting is an epigenetic feature that plays a significant role in carcinogenesis. In this study, we examined the expression status of an imprinted gene, paternally expressed gene 1/mesoderm-specific transcript (PEG1/MEST), in 38 cases of head and neck squamous cell carcinomas (HNSCCs) and in 17 oral squamous cancer cell lines. Loss of imprinting (LOI) of PEG1/MEST was found in 8 of 10 (80%) in tumor specimens, and 6 of 10 (60%) informative cases even in the extracted normal tissue specimens. As for the oral squamous cancer cell lines, LOI was detected in 5 of 8 (62.5%) informative cases in PEG1/MEST. Thus, these data showed that abnormal expression of PEG1/MEST was found at a high frequency in the tumor, the extracted normal tissue specimens and the oral squamous cancer cell lines. PEG1/MEST LOI in extracted normal tissue specimens may have a potential individual cancer risk for HNSCC.

AB - Genomic imprinting is an epigenetic feature that plays a significant role in carcinogenesis. In this study, we examined the expression status of an imprinted gene, paternally expressed gene 1/mesoderm-specific transcript (PEG1/MEST), in 38 cases of head and neck squamous cell carcinomas (HNSCCs) and in 17 oral squamous cancer cell lines. Loss of imprinting (LOI) of PEG1/MEST was found in 8 of 10 (80%) in tumor specimens, and 6 of 10 (60%) informative cases even in the extracted normal tissue specimens. As for the oral squamous cancer cell lines, LOI was detected in 5 of 8 (62.5%) informative cases in PEG1/MEST. Thus, these data showed that abnormal expression of PEG1/MEST was found at a high frequency in the tumor, the extracted normal tissue specimens and the oral squamous cancer cell lines. PEG1/MEST LOI in extracted normal tissue specimens may have a potential individual cancer risk for HNSCC.

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Allele-specific expression analysis of PEG1/MEST in head and neck squamous cell carcinomas

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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