Allele-specific expression analysis of PEG1/MEST in head and neck squamous cell carcinomas

Hideyuki Kataoka, Seiji Nakano, Yasuomi Kunimoto, Naoko Sugie, Mitsuhiko Osaki, Narikazu Uzawa, Mitsuaki A. Yoshida, Mitsuo Oshimura, Hiroya Kitano

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1 Citation (Scopus)

Abstract

Genomic imprinting is an epigenetic feature that plays a significant role in carcinogenesis. In this study, we examined the expression status of an imprinted gene, paternally expressed gene 1/mesoderm-specific transcript (PEG1/MEST), in 38 cases of head and neck squamous cell carcinomas (HNSCCs) and in 17 oral squamous cancer cell lines. Loss of imprinting (LOI) of PEG1/MEST was found in 8 of 10 (80%) in tumor specimens, and 6 of 10 (60%) informative cases even in the extracted normal tissue specimens. As for the oral squamous cancer cell lines, LOI was detected in 5 of 8 (62.5%) informative cases in PEG1/MEST. Thus, these data showed that abnormal expression of PEG1/MEST was found at a high frequency in the tumor, the extracted normal tissue specimens and the oral squamous cancer cell lines. PEG1/MEST LOI in extracted normal tissue specimens may have a potential individual cancer risk for HNSCC.

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalYonago Acta Medica
Volume52
Issue number2
Publication statusPublished - 2009 Jun 1

Keywords

  • Head and neck squamous cell carcinoma
  • Loss of imprinting
  • PEG1/MEST

ASJC Scopus subject areas

  • Medicine(all)

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    Kataoka, H., Nakano, S., Kunimoto, Y., Sugie, N., Osaki, M., Uzawa, N., Yoshida, M. A., Oshimura, M., & Kitano, H. (2009). Allele-specific expression analysis of PEG1/MEST in head and neck squamous cell carcinomas. Yonago Acta Medica, 52(2), 85-90.