Alkyne-Alkyne Photo-cross-linking on the Flipping-out Field

Kazumitsu Onizuka; Kei Ishida; Eriko Mano; Fumi Nagatsugi

doi:10.1021/acs.orglett.9b00817

Alkyne-Alkyne Photo-cross-linking on the Flipping-out Field

Kazumitsu Onizuka, Kei Ishida, Eriko Mano, Fumi Nagatsugi

Division of Organic- and Biomaterials Research

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The base flip-inducing nucleic acids are expected to create a specific field for various chemical reactions. We now report a novel type of base-flip-inducing oligodeoxynucleotide and photo-cross-linking reaction. Two 3-arylethynyl-5-methyl-2-pyridone nucleosides, Ph and An, were synthesized, and their properties were investigated. The alkyne-alkyne photo-cross-linking rapidly proceeded by taking advantage of the base-flipping-out field where two alkynes overlap each other. This photo-cross-linking would be a new candidate to form cross-linked DNAs.

Original language	English
Pages (from-to)	2833-2837
Number of pages	5
Journal	Organic letters
Volume	21
Issue number	8
DOIs	https://doi.org/10.1021/acs.orglett.9b00817
Publication status	Published - 2019 Apr 19

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Alkyne-Alkyne Photo-cross-linking on the Flipping-out Field",

abstract = "The base flip-inducing nucleic acids are expected to create a specific field for various chemical reactions. We now report a novel type of base-flip-inducing oligodeoxynucleotide and photo-cross-linking reaction. Two 3-arylethynyl-5-methyl-2-pyridone nucleosides, Ph and An, were synthesized, and their properties were investigated. The alkyne-alkyne photo-cross-linking rapidly proceeded by taking advantage of the base-flipping-out field where two alkynes overlap each other. This photo-cross-linking would be a new candidate to form cross-linked DNAs.",

author = "Kazumitsu Onizuka and Kei Ishida and Eriko Mano and Fumi Nagatsugi",

year = "2019",

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T1 - Alkyne-Alkyne Photo-cross-linking on the Flipping-out Field

AU - Onizuka, Kazumitsu

AU - Ishida, Kei

AU - Mano, Eriko

AU - Nagatsugi, Fumi

PY - 2019/4/19

Y1 - 2019/4/19

N2 - The base flip-inducing nucleic acids are expected to create a specific field for various chemical reactions. We now report a novel type of base-flip-inducing oligodeoxynucleotide and photo-cross-linking reaction. Two 3-arylethynyl-5-methyl-2-pyridone nucleosides, Ph and An, were synthesized, and their properties were investigated. The alkyne-alkyne photo-cross-linking rapidly proceeded by taking advantage of the base-flipping-out field where two alkynes overlap each other. This photo-cross-linking would be a new candidate to form cross-linked DNAs.

AB - The base flip-inducing nucleic acids are expected to create a specific field for various chemical reactions. We now report a novel type of base-flip-inducing oligodeoxynucleotide and photo-cross-linking reaction. Two 3-arylethynyl-5-methyl-2-pyridone nucleosides, Ph and An, were synthesized, and their properties were investigated. The alkyne-alkyne photo-cross-linking rapidly proceeded by taking advantage of the base-flipping-out field where two alkynes overlap each other. This photo-cross-linking would be a new candidate to form cross-linked DNAs.

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