Alkaline treatments to render starch-based biodegradable polymers self-mineralizable

I. B. Leonor, H. M. Kim, F. Balas, M. Kawashita, R. L. Reis, T. Kokubo, T. Nakamura

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


The present research aims to develop a new route for surface functionalization of biodegradable polymers. The method is based on a wet chemistry modification, resulting in etching and/or hydrolysis in order to increase the amount of polar groups, such as hydroxyl (-OH) and carboxylic (-COOH) groups on the surface of the polymer. The polymer used as substrate was a corn starch-ethylene vinyl alcohol biodegradable blend (SEVA-C). For that purpose it was used in two different types of activation: (a) calcium hydroxide solution [Ca(OH)2] and (b) sodium hydroxide solution (NaOH). These treatments lead to the formation carboxylic acid-rich SEVA-C surfaces. Then, the samples were soaked in simulated body fluid (SBF) for different time periods of time until 7 days. After 1 day in SBF, the surface of SEVA-C was fully covered with spherulite particles. As the soaking time increased, the particles increased and coalesced, leading to the formation of a dense and uniform layer. Furthermore, thin-film X-ray diffraction confirms that the layer formed on the surface of the polymer was an apatite-like layer. These results suggest that this rather simple treatment is a good method for surface functionalization and subsequent mineral nucleation and growth on biodegradable polymeric surfaces to be used for bone-related applications.

Original languageEnglish
Pages (from-to)425-435
Number of pages11
JournalJournal of Tissue Engineering and Regenerative Medicine
Issue number6
Publication statusPublished - 2007
Externally publishedYes


  • Apatite
  • Bioactivity
  • Biodegradable polymer
  • Functional groups
  • Simulated body fluid (SBF)
  • Starch-based polymers

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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