Aldosterone synthase gene (CYP11B2) C-334T polymorphism, ambulatory blood pressure and nocturnal decline in blood pressure in the general Japanese population: The Ohasama study

Mitsunobu Matsubara, Masahiro Kikuya, Takayoshi Ohkubo, Hirohito Metoki, Fumiko Omori, Tohru Fujiwara, Michiko Suzuki, Mari Michimata, Atsushi Hozawa, Tomohiro Katsuya, Jitsuo Higaki, Ichiro Tsuji, Tsutomu Araki, Toshio Ogihara, Hiroshi Satoh, Shigeru Hisamichi, Kenichi Nagai, Hirofumi Kitaoka, Yutaka Imai

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

Objective: The C-344T polymorphism in the 5′-flanking region of the aldosterone synthase (CYP11B2) gene has been suggested to be associated with hypertension and disturbed circadian blood pressure (BP) rhythm through its effect on aldosterone synthesis. However, previous findings on this topic have been inconsistent. Design: A cross-sectional study. Subjects and methods: We investigated the CYP11B2 C-344T genotype in 802 subjects, aged 40 and over, in a Japanese community, who gave written informed consent and were monitored for 24 h ambulatory BP. Results: The frequencies of the CC, CT, and TT genotypes in these Japanese subjects were 0.14, 0.44, and 0.42, showing a higher frequency of the T allele (0.64) than in Caucasians. Although there was no significant difference in 24 h ambulatory BP levels among the genotypes, the nocturnal decline in BP was significantly greater in the CC homozygous subjects than in other subjects (P=0.0065 for systolic and P=0.031 for diastolic decline in nocturnal BP). Detailed analyses demonstrated that this association was significant only in aged (60 years and over) or male subjects. The prevalence of previous cardiovascular disease was significantly less in these subjects with the CC genotype than in those with the TC and TT genotypes, although age, body mass index, male gender, smoking, use of alcohol and antihypertensive medication did not differ among the three genotypes. There was no significant difference among the three genotypes in biochemical and hormonal parameters. Conclusion: Although the C-344 T polymorphism of CYP11B2 did not directly influence the level of 24 h BP, the CC genotype was associated with decreased nocturnal BP in elderly or male Japanese. Since prevalence of previous cardiovascular disease was significantly less in homozygous CC subjects, greater nocturnal BP decline in this genotype appears to be beneficial in the circadian BP rhythm.

Original languageEnglish
Pages (from-to)2179-2184
Number of pages6
JournalJournal of hypertension
Volume19
Issue number12
DOIs
Publication statusPublished - 2001

Keywords

  • Ambulatory blood pressure
  • Cardiovascular diseases
  • Circadian blood pressure variation
  • Genome
  • Hypertension
  • Nocturnal blood pressure decline

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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