Aldosterone-Producing Cell Clusters in Normal and Pathological States

Kei Omata, Scott A. Tomlins, William E. Rainey

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Primary aldosteronism (PA) significantly increases the risk of cardiovascular complications, and early diagnosis and targeted treatment based on its pathophysiology is warranted. Next-generation sequencing (NGS) has revealed recurrent somatic mutations in aldosterone-driving genes in aldosterone-producing adenoma (APA). By applying CYP11B2 (aldosterone synthase) immunohistochemistry and NGS to adrenal glands from normal subjects and PA patients, we and others have shown that CYP11B2-positive cells make small clusters, termed aldosterone-producing cell clusters (APCC), beneath the adrenal capsule, and that APCC harbor somatic mutations in genes mutated in APA. We have shown that APCC are increased in CT-negative PA adrenals, while others showed potential progression from APCC to micro APA through mutations. These results suggest that APCC are a key factor for understanding the origin of PA, and further investigation on the relation between APCC and PA is highly needed.

Original languageEnglish
Pages (from-to)951-956
Number of pages6
JournalHormone and Metabolic Research
Volume49
Issue number12
DOIs
Publication statusPublished - 2017 Dec 1

Keywords

  • aldosterone-producing cell clusters
  • next-generation sequencing
  • primary aldosteronism

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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