Aldosterone biosynthesis in the human adrenal cortex and associated disorders

Yasuhiro Nakamura, Yuto Yamazaki, Sachiko Konosu-Fukaya, Kazue Ise, Fumitoshi Satoh, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Aldosterone is one of the mineralocorticoids synthesized and secreted by the adrenal glands, and it plays pivotal roles in regulating extracellular fluid volume and blood pressure. Autonomous excessive aldosterone secretion resulting from adrenocortical diseases is known as primary aldosteronism, and it constitutes one of the most frequent causes of secondary hypertension. Therefore, it is important to understand the molecular mechanisms of aldosterone synthesis in both normal and pathological adrenal tissues. Various factors have been suggested to be involved in regulation of aldosterone biosynthesis, and several adrenocortical cell lines have been developed for use as in vitro models of adrenal aldosterone-producing cells, for analysis of the underlying molecular mechanisms. In this review, we summarize the available reports on the regulation of aldosterone biosynthesis in the normal adrenal cortex, in associated disorders, and in in vitro models.

Original languageEnglish
Article number4418
Pages (from-to)57-62
Number of pages6
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume153
DOIs
Publication statusPublished - 2015 Sep 1
Externally publishedYes

Keywords

  • Adrenal gland
  • Aldosterone
  • Steroidogenic enzymes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

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