Alcohol drinking and primary liver cancer: A pooled analysis of four Japanese cohort studies

Taichi Shimazu, Shizuka Sasazuki, Kenji Wakai, Akiko Tamakoshi, Ichiro Tsuji, Yumi Sugawara, Keitaro Matsuo, Chisato Nagata, Tetsuya Mizoue, Keitaro Tanaka, Manami Inoue, Shoichiro Tsugane

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Because studies of the association between alcohol intake and the risk of primary liver cancer use varying cut-off points to classify alcohol intake, it is difficult to precisely quantify this association by meta-analysis of published data. Furthermore, there are limited data for women in prospective studies of the dose-specific relation of alcohol intake and the risk of primary liver cancer. We analyzed original data from 4 population-based prospective cohort studies encompassing 174,719 participants (89,863 men and 84,856 women). After adjustment for a common set of variables, we used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of primary liver cancer incidence according to alcohol intake. We conducted a meta-analysis of the HRs derived from each study. During 1,964,136 person-years of follow-up, 804 primary liver cancer cases (605 men and 199 women) were identified. In male drinkers, the multivariate-adjusted HRs (95% CI) for alcohol intakes of 0.1-22.9, 23.0-45.9, 46.0-68.9, 69.0-91.9 and ≥92.0 g/day, as compared to occasional drinkers, were 0.88 (0.57-1.36), 1.06 (0.70-1.62), 1.07 (0.69-1.66), 1.76 (1.08-2.87) and 1.66 (0.98-2.82), respectively (p for trend = 0.015). In women, we observed a significantly increased risk among those who drank ≥23.0 g/day, as compared to occasional drinkers (HR: 3.60; 95% CI: 1.22-10.66). This pooled analysis of data from large prospective studies in Japan indicates that avoidance of (1) heavy alcohol drinking (≥69.0 g alcohol/day) in men and (2) moderate drinking (≥23.0 g alcohol/day) in women may reduce the risk of primary liver cancer.

Original languageEnglish
Pages (from-to)2645-2653
Number of pages9
JournalInternational Journal of Cancer
Volume130
Issue number11
DOIs
Publication statusPublished - 2012 Jun 1

Keywords

  • alcohols
  • cohort studies
  • liver neoplasms
  • pooled analysis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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