Alcohol drinking and esophageal cancer risk: An evaluation based on a systematic review of epidemiologic evidence among the Japanese population

Isao Oze, Keitaro Matsuo, Kenji Wakai, Chisato Nagata, Tetsuya Mizoue, Keitaro Tanaka, Ichiro Tsuji, Shizuka Sasazuki, Manami Inoue, Shoichiro Tsugane

Research output: Contribution to journalReview articlepeer-review

56 Citations (Scopus)

Abstract

Although alcohol drinking is considered as an important risk factor for esophageal cancer, the magnitude of the association might be varied among geographic areas. Therefore, we reviewed epidemiologic studies on the association between alcohol drinking and esophageal cancer among the Japanese population. Original data were obtained from MEDLINE, searched using PubMed or from searches of the Ichushi database, complemented with manual searches. Evaluation of associations was based on the strength of evidence ('convincing', 'probable', 'possible' or 'insufficient') and the magnitude of association ('strong', 'moderate', 'weak' or 'no association'), together with biological plausibility as previously evaluated by the International Agency of Research on Cancer. We identified four cohort studies and nine case-control studies. All cohort studies and case-control studies showed strong positive associations between esophageal cancer and alcohol drinking. All cohort studies and six case-control studies showed that alcohol drinking had the dose- or frequency-response relationships with esophageal cancer. In addition, four case-control studies showed that acetaldehyde dehydrogenase Glu504Lys polymorphism had strong effect modification with alcohol drinking. We conclude that there is convincing evidence that alcohol drinking increases the risk of esophageal cancer in the Japanese population.

Original languageEnglish
Article numberhyr026
Pages (from-to)677-692
Number of pages16
JournalJapanese journal of clinical oncology
Volume41
Issue number5
DOIs
Publication statusPublished - 2011 May

Keywords

  • Alcohol drinking
  • Epidemiology
  • Esophageal cancer
  • Japanese
  • Systematic review

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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