Alcohol drinking and breast cancer risk: An evaluation based on a systematic review of epidemiologic evidence among the Japanese population

Chisato Nagata, Tetsuya Mizoue, Keitaro Tanaka, Ichiro Tsuji, Kenji Wakai, Manami Inoue, Shoichiro Tsugane

Research output: Contribution to journalReview articlepeer-review

29 Citations (Scopus)

Abstract

Background: We reviewed epidemiological studies on alcohol drinking and breast cancer among the Japanese population. This report is one among a series of articles by our research group evaluating the existing evidence concerning the association between health-related lifestyles and cancer. Methods: Original data were obtained from MEDLINE searches using PubMed or from searches of the Ichushi database, complemented with manual searches. Evaluation of associations was based on the strength of evidence and the magnitude of association, together with biological plausibility as previously evaluated by the International Agency for Research on Cancer. Results: Three cohort studies and eight case-control studies were identified. There were inconsistent results regarding alcohol drinking and breast cancer risk among cohort studies. A significant positive association was observed in one, but another showed nonsignificant inverse association. Out of the eight case-control studies, two studies showed a significantly increased risk among women who drink daily and who had higher intake of alcohol, respectively. Experimental studies have supported the biological plausibility of a positive association between alcohol drinking and breast cancer risk. Conclusion: We conclude that epidemiologic evidence on the association between alcohol drinking and breast cancer risk remains insufficient in terms of both the number and methodological quality of studies among the Japanese population.

Original languageEnglish
Pages (from-to)568-574
Number of pages7
JournalJapanese journal of clinical oncology
Volume37
Issue number8
DOIs
Publication statusPublished - 2007 Aug

Keywords

  • Alcohol drinking
  • Breast cancer
  • Epidemiology
  • Japanese
  • Systematic review

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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