Alcohol consumption and the risk for developing pancreatitis: A case-control study in Japan

Kiyoshi Kume, Atsushi Masamune, Hiroyuki Ariga, Tooru Shimosegawa

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Objective: This study aimed to estimate the association of alcohol consumption and pancreatitis in Japan. Methods:We performed a nationwide case-control study,which included 982 patients (574 patients with acute pancreatitis and 408 patients with chronic pancreatitis) and 1015 controls who were individually matched for sex, age, hospital, and time of their first hospital visit. Conditional logistic regression was used to assess the association of alcohol consumption and smoking with pancreatitis. Results: The patients had a mean (SD) age of 57.6 (17.0) years; 71.8% were male. Compared with nondrinkers, alcohol consumption of less than 20 g/d was not associated with the risk for total pancreatitis (odds ratio [OR], 1.0; 95% confidence interval [CI], 0.7-1.4). In patients with acute pancreatitis, the ORs (95% CI) for alcohol consumption of 20 ≤ ∼ < 40 g/d, 40≤∼< 60 g/d, 60≤∼< 80 g/d, 80≤∼< 100 g/d, and 100 g/d or greater were 1.7 (0.9-3.0), 3.1 (1.6-5.9), 4.2 (2.1-8.2), 5.3 (2.4-12.0), and 6.4 (3.4-12.4), respectively. In patients with chronic pancreatitis, the ORs (95% CI) for alcohol consumption of 20 ≤ ∼ < 40 g/d, 40 ≤ ∼ < 60 g/d, 60 ≤ ∼ < 80 g/d, 80 ≤ ∼ < 100 g/d, and 100 g/d or greater were 2.6 (1.2-5.5), 3.2 (1.5-7.1), 9.2 (4.1-20.3), 13.0 (5.3-31.6), and 19.6 (8.2-46.8), respectively. Conclusions: Our study precisely measured the quantitative effect of alcohol on the risk for developing pancreatitis.

Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalPancreas
Volume44
Issue number1
DOIs
Publication statusPublished - 2015 Jan

Keywords

  • Acute pancreatitis
  • Chronic pancreatitis
  • Ethanol
  • Nationwide survey
  • Smoking

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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