Alcohol consumption and lung cancer mortality in Japanese men: Results from Japan collaborative cohort (JACC) study

Yoshikazu Nishino, Kenji Wakai, Takaaki Kondo, Nao Seki, Yoshinori Ito, Koji Suzuki, Kotaro Ozasa, Yoshiyuki Watanabe, Masahiko Ando, Yoshitaka Tsubono, Ichiro Tsuji, Akiko Tamakoshi, Mitsuru Mori, Yutaka Motohashi, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Yutaka Inaba, Yoshiharu Hoshiyama, Hiroshi SuzukiHiroyuki Shimizu, Hideaki Toyoshima, Shinkan Tokudome, Shuji Hashimoto, Shogo Kikuchi, Akio Koizumi, Takashi Kawamura, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Norihiko Hayakawa, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: The relationship between alcohol consumption and increased risk of lung cancer is controversial. This study was set up to investigate the association between alcohol consumption and death from lung cancer in a large Japanese cohort. Methods: The subjects comprised 28,536 males, aged 40-79 years, living throughout Japan. During 268,464 person-years of follow-up, 377 lung cancer deaths were recorded. The hazard ratio (HR) of alcohol consumption for lung cancer mortality was calculated using the Cox proportional hazards model after adjustment for age, smoking and family history of lung cancer. Results: There was no association between increased mortality from lung cancer and alcohol consumption among current drinkers. Compared with subjects who had never drunk alcohol, the HRs (95% confidence interval [Cl]) of death from lung cancer for light (consuming <25.0 g ethanol per day), moderate (25.0-49.9 g per day) and heavy (≥50 g per day) drinkers were 0.81 (95% Cl=0.61-1.07), 0.82 (0.61-1.11) and 0.97 (0.66-1.43), respectively. Further adjustment for fruit and vegetable intake did not change the results, and there was no change in HR materially after excluding those patients who died during the first 5 years of follow-up. Conclusions: These findings indicate that alcohol consumption was not associated with increased lung cancer mortality in this population of Japanese men.

Original languageEnglish
Pages (from-to)49-56
Number of pages8
Journaljournal of epidemiology
Volume16
Issue number2
DOIs
Publication statusPublished - 2006 Mar 14

Keywords

  • Alcohol drinking
  • Cohort studies
  • Fruit
  • Lung neoplasms
  • Vegetables

ASJC Scopus subject areas

  • Epidemiology

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    Nishino, Y., Wakai, K., Kondo, T., Seki, N., Ito, Y., Suzuki, K., Ozasa, K., Watanabe, Y., Ando, M., Tsubono, Y., Tsuji, I., Tamakoshi, A., Mori, M., Motohashi, Y., Nakamura, Y., Iso, H., Mikami, H., Inaba, Y., Hoshiyama, Y., ... Tajima, K. (2006). Alcohol consumption and lung cancer mortality in Japanese men: Results from Japan collaborative cohort (JACC) study. journal of epidemiology, 16(2), 49-56. https://doi.org/10.2188/jea.16.49