Alcohol consumption and colorectal cancer risk: Findings from the JACC Study

Kenji Wakai, Masayo Kojima, Koji Tamakoshi, Yoshiyuki Watanabe, Norihiko Hayakawa, Koji Suzuki, Shuji Hashimoto, Miyuki Kawado, Shinkan Tokudome, Sadao Suzuki, Kotaro Ozasa, Hideaki Toyoshima, Yoshinori Ito, Akiko Tamakoshi, Mitsuru Mori, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo MikamiYutaka Inaba, Yoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Shogo Kikuchi, Akio Koizumi, Takashi Kawamura, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Because alcohol drinking is a potential risk factor for colorectal cancer, the trend in alcohol consumption in Japan may partly explain the increase in incidence and mortality rates of this malignancy until 1990-1995. Methods: We analyzed data from the Japan Collaborative Cohort Study. From 1988 to 1990, 23,708 men and 34,028 women, aged 40-79 years, completed a questionnaire on lifestyle factors including drinking habits. Incidence rate ratios (IRR) were estimated by using proportional hazards models. Results: During the mean follow-up of 7.6 years through December 1997, we documented 418 incidents of colon cancer and 211 of rectal cancer. Male ex- or current drinkers demonstrated a twofold risk for colon cancer compared with nondrinkers: the multivariate-adjusted IRR was 2.01 (95% confidence interval [CI] 1.09-3.68) for ex-drinkers and 1.97 (95% Cl: 1.28-3.03) for current drinkers. The dose-response relationship between alcohol consumption and the risk, however, was not clear. Female ex-drinkers were at an increased risk without statistical significance. For rectal cancer, we found a slightly lower risk in light current drinkers who consumed less than 22 g ethanol per day: the multivariate IRR was 0.61 (95% Cl: 0.33-1.13) for men and 0.69 (95% Cl: 0.27-1.74) for women. Although the IRR for all current drinkers was almost unity in men, an increasing trend in risk was detected with increasing alcohol consumption in current drinkers (trend p = 0.027). Conclusions: Taking the findings from our study and other prospective investigations into consideration, more attention should be paid to alcohol consumption in the prevention of colon cancer in Japan.

Original languageEnglish
Pages (from-to)S173-S179
Journaljournal of epidemiology
Volume15
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 2005

Keywords

  • Alcohol drinking
  • Cohort studies
  • Colon neoplasms
  • Rectal neoplasms

ASJC Scopus subject areas

  • Epidemiology

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  • Cite this

    Wakai, K., Kojima, M., Tamakoshi, K., Watanabe, Y., Hayakawa, N., Suzuki, K., Hashimoto, S., Kawado, M., Tokudome, S., Suzuki, S., Ozasa, K., Toyoshima, H., Ito, Y., Tamakoshi, A., Mori, M., Motohashi, Y., Tsuji, I., Nakamura, Y., Iso, H., ... Tajima, K. (2005). Alcohol consumption and colorectal cancer risk: Findings from the JACC Study. journal of epidemiology, 15(SUPPL. 2), S173-S179. https://doi.org/10.2188/jea.15.S173