TY - JOUR
T1 - AILIM/ICOS signaling induces T-cell migration/polarization of memory/effector T-cells
AU - Okamoto, Naokazu
AU - Nukada, Yuko
AU - Tezuka, Katsunari
AU - Ohashi, Kazumasa
AU - Mizuno, Kensaku
AU - Tsuji, Takashi
PY - 2004/10
Y1 - 2004/10
N2 - AILIM/ICOS has critical roles in the regulation of T-cell differentiation and effector T-cell function in various immune responses. The counter-ligand for AILIM/ICOS, B7h, is widely expressed in not only lymphoid tissue and antigen-presenting cells, but also in fibroblast and endothelial cells in various organs. Here, we demonstrate that activated human T-cells migrate beneath TNF-α-treated HUVEC and display morphological polarization via AILIM/ICOS signaling. AILIM/ICOS stimulation, in the absence of antigen stimulation, also induced T-cell polarization. Importantly, AILIM/ICOS-mediated polarization was evident in CD4+CD45RO+ memory T-cells and generated Th1 cells, but not in CD4+CD45RA+ naive T-cells and generated Th2 cells. Furthermore, AILIM/ICOS signaling is involved in transendothelial migration of Th1 cells, but not Th2 cells. Our data suggest that AILIM/ICOS-B7h interactions play an important role in the endothelium in controlling the entry of memory/effector T-cells into inflamed tissues in the periphery.
AB - AILIM/ICOS has critical roles in the regulation of T-cell differentiation and effector T-cell function in various immune responses. The counter-ligand for AILIM/ICOS, B7h, is widely expressed in not only lymphoid tissue and antigen-presenting cells, but also in fibroblast and endothelial cells in various organs. Here, we demonstrate that activated human T-cells migrate beneath TNF-α-treated HUVEC and display morphological polarization via AILIM/ICOS signaling. AILIM/ICOS stimulation, in the absence of antigen stimulation, also induced T-cell polarization. Importantly, AILIM/ICOS-mediated polarization was evident in CD4+CD45RO+ memory T-cells and generated Th1 cells, but not in CD4+CD45RA+ naive T-cells and generated Th2 cells. Furthermore, AILIM/ICOS signaling is involved in transendothelial migration of Th1 cells, but not Th2 cells. Our data suggest that AILIM/ICOS-B7h interactions play an important role in the endothelium in controlling the entry of memory/effector T-cells into inflamed tissues in the periphery.
KW - Costimulatory molecule
KW - Inflammation
KW - Transendothelial migration
UR - http://www.scopus.com/inward/record.url?scp=5044252450&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=5044252450&partnerID=8YFLogxK
U2 - 10.1093/intimm/dxh153
DO - 10.1093/intimm/dxh153
M3 - Article
C2 - 15339883
AN - SCOPUS:5044252450
VL - 16
SP - 1515
EP - 1522
JO - International Immunology
JF - International Immunology
SN - 0953-8178
IS - 10
ER -