AILIM/ICOS signaling induces T-cell migration/polarization of memory/effector T-cells

Naokazu Okamoto, Yuko Nukada, Katsunari Tezuka, Kazumasa Ohashi, Kensaku Mizuno, Takashi Tsuji

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

AILIM/ICOS has critical roles in the regulation of T-cell differentiation and effector T-cell function in various immune responses. The counter-ligand for AILIM/ICOS, B7h, is widely expressed in not only lymphoid tissue and antigen-presenting cells, but also in fibroblast and endothelial cells in various organs. Here, we demonstrate that activated human T-cells migrate beneath TNF-α-treated HUVEC and display morphological polarization via AILIM/ICOS signaling. AILIM/ICOS stimulation, in the absence of antigen stimulation, also induced T-cell polarization. Importantly, AILIM/ICOS-mediated polarization was evident in CD4+CD45RO+ memory T-cells and generated Th1 cells, but not in CD4+CD45RA+ naive T-cells and generated Th2 cells. Furthermore, AILIM/ICOS signaling is involved in transendothelial migration of Th1 cells, but not Th2 cells. Our data suggest that AILIM/ICOS-B7h interactions play an important role in the endothelium in controlling the entry of memory/effector T-cells into inflamed tissues in the periphery.

Original languageEnglish
Pages (from-to)1515-1522
Number of pages8
JournalInternational immunology
Volume16
Issue number10
DOIs
Publication statusPublished - 2004 Oct

Keywords

  • Costimulatory molecule
  • Inflammation
  • Transendothelial migration

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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