Agonistic action of synthetic analogues of quisqualic acid at the insect neuromuscular junction

T. Miyamoto, M. Oda, D. Yamamoto, Junko Kaneko, Toako Usui, J. Fukami

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    One hundred twenty analogues of quisqualic acid were synthesized and assayed on the neuromuscular junction of larva of the mealworm, Tenebrio molitor. Two new agonists for amino acid receptors, L‐glutamic acid N‐thiocarboxyanhydride (L‐GANTA) and DL‐hydantoinpropionic acid (DL‐HPA), were discovered in this study. L‐GANTA and DL‐HPA produced muscle membrane depolarization, accompanied by a reduction of the muscle input resistance. The amplitude of excitatory postsynaptic potentials was decreased in the presence of L‐GANTA and DL‐HPA. The apparent dissociation constants obtained from dose‐depolarization plots were 7 x 10−4 M for L‐GANTA and 9 x 10−4 M for DL‐HPA. Some structural constraints imposed on agonists at amino acid receptors on insect muscle were discussed.

    Original languageEnglish
    Pages (from-to)65-73
    Number of pages9
    JournalArchives of Insect Biochemistry and Physiology
    Volume2
    Issue number1
    DOIs
    Publication statusPublished - 1985

    Keywords

    • amino acid receptors
    • mealworm muscle
    • new agonists
    • quisqualate analogues

    ASJC Scopus subject areas

    • Physiology
    • Biochemistry
    • Insect Science

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