Ag/FeCo/Ag core/shell/shell magnetic nanoparticles with plasmonic imaging capability

Mari Takahashi, Priyank Mohan, Akiko Nakade, Koichi Higashimine, Derrick Mott, Tsutomu Hamada, Kazuaki Matsumura, Tomohiko Taguchi, Shinya Maenosono

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Magnetic nanoparticles (NPs) have been used to separate various species such as bacteria, cells, and proteins. In this study, we synthesized Ag/FeCo/Ag core/shell/shell NPs designed for magnetic separation of subcellular components like intracellular vesicles. A benefit of these NPs is that their silver metal content allows plasmon scattering to be used as a tool to observe detection by the NPs easily and semipermanently. Therefore, these NPs are considered a potential alternative to existing fluorescent probes like dye molecules and colloidal quantum dots. In addition, the Ag core inside the NPs suppresses the oxidation of FeCo because of electron transfer from the Ag core to the FeCo shell, even though FeCo is typically susceptible to oxidation. The surfaces of the Ag/FeCo/Ag NPs were functionalized with ε-poly-l-lysine-based hydrophilic polymers to make them water-soluble and biocompatible. The imaging capability of the polymer-functionalized NPs induced by plasmon scattering from the Ag core was investigated. The response of the NPs to a magnetic field using liposomes as platforms and applying a magnetic field during observation by confocal laser scanning microscopy was assessed. The results of the magnetophoresis experiments of liposomes allowed us to calculate the magnetic force to which each liposome was subjected.

Original languageEnglish
Pages (from-to)2228-2236
Number of pages9
JournalLangmuir
Volume31
Issue number7
DOIs
Publication statusPublished - 2015 Feb 24
Externally publishedYes

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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