In therapeutic application of ultrasound, promotion and suppression of cavitational effects are both important. We have reported that rose bengal (RB) can reduce the intensity threshold for cavitation in murine liver tissue. This effect was pharmacokinetically studied in this paper. It decreased gradually as the time elapsed after the RB administration, but not as rapidly as the decrease in RB concentration in the liver. As for chemicals suppressing aqueous cavitation, we found that sodium ascorbate is quite effective.
|Number of pages||4|
|Journal||Proceedings of the IEEE Ultrasonics Symposium|
|Publication status||Published - 1998 Dec 1|
|Event||Proceedings of the 1998 International Ultrasonics Symposium - Sendai, Miyagi, Jpn|
Duration: 1998 Oct 5 → 1998 Oct 8
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