TY - JOUR
T1 - Age-related changes in lipid metabolism in rats
T2 - the consequence of moderate food restriction
AU - Choi, Yong Soon
AU - Goto, Shoichiro
AU - Ikeda, Ikuo
AU - Sugano, Michihiro
PY - 1988/11/25
Y1 - 1988/11/25
N2 - Male Sprague-Dawley rats, 3 weeks of age, received one of the four following dietary manipulations until 9 months of age: group AD, fed ad libitum; group R, restricted to 75% of food intake of group AD; group RAD, restricted until 5 months of age and then fed ad libitum; group ADR, fed ad libitum until 5 months of age and then restricted. The concentration of serum total and HDL cholesterol tended to be higher in group AD than in all groups that had experienced food restriction. Liver cholesterol was higher in groups AD and RAD than in groups R and ADR. Activity of hepatic microsomal hydroxymethylglutaryl-CoA reductase was comparable, whereas sterol synthesis from mevalonate was significantly higher in groups R and ADR than in groups AD and RAD. Cholesterol 7α-hydroxylase activity also tended to be higher in groups R and ADR. It seems likely that hepatic cholesterol homeostasis functions effectively even when moderate food restriction was started after the growing period. In addition, food restriction reduced the ratio of arachidonate to linoleate, suggesting inhibition of the desaturation system.
AB - Male Sprague-Dawley rats, 3 weeks of age, received one of the four following dietary manipulations until 9 months of age: group AD, fed ad libitum; group R, restricted to 75% of food intake of group AD; group RAD, restricted until 5 months of age and then fed ad libitum; group ADR, fed ad libitum until 5 months of age and then restricted. The concentration of serum total and HDL cholesterol tended to be higher in group AD than in all groups that had experienced food restriction. Liver cholesterol was higher in groups AD and RAD than in groups R and ADR. Activity of hepatic microsomal hydroxymethylglutaryl-CoA reductase was comparable, whereas sterol synthesis from mevalonate was significantly higher in groups R and ADR than in groups AD and RAD. Cholesterol 7α-hydroxylase activity also tended to be higher in groups R and ADR. It seems likely that hepatic cholesterol homeostasis functions effectively even when moderate food restriction was started after the growing period. In addition, food restriction reduced the ratio of arachidonate to linoleate, suggesting inhibition of the desaturation system.
KW - (Rat)
KW - Age
KW - Lipid metabolism
KW - Nutrition
KW - Sterol synthesis
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U2 - 10.1016/0005-2760(88)90286-X
DO - 10.1016/0005-2760(88)90286-X
M3 - Article
C2 - 3196729
AN - SCOPUS:0023804379
VL - 963
SP - 237
EP - 242
JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
SN - 1388-1981
IS - 2
ER -