Age at onset and visuocognitive disturbances in Alzheimer disease

Misato Fujimori, Toru Imamura, Hikari Yamashita, Nobutsugu Hirono, Yoshitaka Ikejiri, Tatsuo Shimomura, Etsuro Mori

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)

Abstract

We examined the relation of age at onset and visuocognitive disturbances in Alzheimer disease (AD) using a large sample of patients, quantitative neuropsychological measures, and multivariate statistics controlling for gender, education, stage of dementia, and disease duration. Significant positive coefficients were obtained with forward and backward digit and visual spans, visual counting, copying Rey complex figure, and block design task. The results indicated that patients with early-onset AD performed worse than late-onset AD patients on these tasks. There was no significant effect of age at onset on identification of overlapping figures, visual form discrimination, or Raven's colored progressive matrices. These findings confirm the greater attentional and visuospatial impairments in early onset patients when these confounding factors were controlled for, although no significant effect of age at onset in visuoperceptual function was observed.

Original languageEnglish
Pages (from-to)163-166
Number of pages4
JournalAlzheimer Disease and Associated Disorders
Volume12
Issue number3
DOIs
Publication statusPublished - 1998 Sep

Keywords

  • Alzheimer disease
  • Attentional function
  • Neuropsychology
  • Senile dementia of the Alzheimer type
  • Visuoperceptual disturbance
  • Visuospatial disturbance

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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