Age at onset and regional cerebral glucose metabolism in Alzheimer's disease

Fumihiko Yasuno, Toru Imamura, Nobutsugu Hirono, Kazunari Ishii, Masahiro Sasaki, Yoshitaka Ikejiri, Mamoru Hashimoto, Tatsuo Shimomura, Hikari Yamashita, Etsuro Mori

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


This study assessed 46 patients with Alzheimer's disease and 21 aged controls using positron emission tomography. Repeated analyses using a general linear model examined the effect of age at onset on the pattern of the regional cerebral metabolic rate of glucose (rCMRglc). The results showed significant age effects on the rCMRglc in the fronto-temporo-parietal association cortices and retrosplenial areas. Disease duration, overall cognitive severity or normal aging could not account for the effects. The age effects were delineated as a double dissociation, that is, early-onset patients have a more severe reduction of regional glucose metabolism in the association cortices, while late-onset patients show a more prominent metabolic deficit in the paralimbic area.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalDementia and geriatric cognitive disorders
Issue number2
Publication statusPublished - 1998 Jan 1


  • Age at onset
  • Alzheimer's disease
  • Association cortex
  • Cerebral glucose metabolism
  • Paralimbic area
  • Positron emission tomography

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health


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