TY - JOUR
T1 - Age- and sex-dependency of laser speckle flowgraphy measurements of optic nerve vessel microcirculation
AU - Aizawa, Naoko
AU - Kunikata, Hiroshi
AU - Nitta, Fumihiko
AU - Shiga, Yukihiro
AU - Omodaka, Kazuko
AU - Tsuda, Satoru
AU - Nakazawa, Toru
N1 - Funding Information:
Support was provided by a JST grant from JSPS KAKENHI Grants-in-Aid for Scientific Research (B) (TN 26293372), Scientific Research (C) (HK 26462629), and Exploratory Research (TN 26670751). The funder had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Informed consent for treatment and participation in the research for this retrospective study was obtained from all patients. The institutional review board of Tohoku University Graduate School of Medicine approved this study. The principal investigator, Dr. Naoko Aizawa, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. No authors have any potential conflicts of interest to disclose. The authors would like to express our gratitude to Shinji Onodera (NTT East Japan Tohoku Hospital), Shinobu Saito, Rie Taima, Nobuko Tsuda and Megumi Nagano (Sendai Open Hospital) for their support of this study. This paper was supported in part by a JST grant from JSPS KAKENHI Grants-in-Aid for Scientific Research (B) (T.N. 26293372), for Scientific Research (C) (H.K. 26462629), and for Exploratory Research (T.N. 26670751). The funders had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
PY - 2016/2
Y1 - 2016/2
N2 - Purpose: To investigate the relationship between various characteristics of a normal population and laser speckle flowgraphy (LSFG) measurements of mean blur rate (MBR) in the optic nerve head (ONH). Methods: A total of 189 eyes of 189 normal subjects (93 male, 96 female, mean age 45 ± 14 years old, age range: 20-72) without any history of hypertension, hyperlipidemia or diabetes were enrolled. ONH microcirculation was measured with LSFG and overall MBR (MA), vesselarea MBR (MV), and tissue-area MBR (MT) were derived from these measurements. The statistical association of these measurements with characteristics such as sex, age, intraocular pressure (IOP) and systolic blood pressure (SBP) was then determined. Results: There was a trend towards decreased IOP and MV and increased SBP with age (P = 0.002, P = 0.035, and P = 0.006, respectively). Furthermore, IOP, MV and SBP were correlated with age (r = -0.23, P = 0.011; r = -0.24, P < 0.001; and r = 0.30, P < 0.001, respectively). Separate multiple regression analyses of independent contributing factors revealed that sex and IOP contributed to MA (P < 0.001 and P = 0.002, respectively), sex, IOP, and age contributed to MV (P < 0.001, P = 0.003, and P = 0.024, respectively), while only IOP contributed to MT (P = 0.003). Conclusion: In a normal population, MBR was affected by IOP in both the large vessel and capillary areas of the ONH, but not by SBP. MV was also affected by age and sex, while MT was stable independent of age or sex.
AB - Purpose: To investigate the relationship between various characteristics of a normal population and laser speckle flowgraphy (LSFG) measurements of mean blur rate (MBR) in the optic nerve head (ONH). Methods: A total of 189 eyes of 189 normal subjects (93 male, 96 female, mean age 45 ± 14 years old, age range: 20-72) without any history of hypertension, hyperlipidemia or diabetes were enrolled. ONH microcirculation was measured with LSFG and overall MBR (MA), vesselarea MBR (MV), and tissue-area MBR (MT) were derived from these measurements. The statistical association of these measurements with characteristics such as sex, age, intraocular pressure (IOP) and systolic blood pressure (SBP) was then determined. Results: There was a trend towards decreased IOP and MV and increased SBP with age (P = 0.002, P = 0.035, and P = 0.006, respectively). Furthermore, IOP, MV and SBP were correlated with age (r = -0.23, P = 0.011; r = -0.24, P < 0.001; and r = 0.30, P < 0.001, respectively). Separate multiple regression analyses of independent contributing factors revealed that sex and IOP contributed to MA (P < 0.001 and P = 0.002, respectively), sex, IOP, and age contributed to MV (P < 0.001, P = 0.003, and P = 0.024, respectively), while only IOP contributed to MT (P = 0.003). Conclusion: In a normal population, MBR was affected by IOP in both the large vessel and capillary areas of the ONH, but not by SBP. MV was also affected by age and sex, while MT was stable independent of age or sex.
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U2 - 10.1371/journal.pone.0148812
DO - 10.1371/journal.pone.0148812
M3 - Article
C2 - 26872348
AN - SCOPUS:84960540536
VL - 11
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 2
M1 - e0148812
ER -