Affinity of a vancomycin polymer with bacterial surface models

Hirokazu Arimoto, Takehisa Oishi, Manabu Nishijima, Tomoya Kinumi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The affinity between a vancomycin polymer (3) and cell wall intermediate mimics of vancomycin resistant bacteria (VRE) was determined by use of surface plasmon resonance (SPR). The increased affinity of 3 over monomeric vancomycin derivatives 1 and 2 suggests the importance of tighter binding to VRE surfaces in the enhanced antibacterial activities of 3.

Original languageEnglish
Pages (from-to)3347-3350
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number19
DOIs
Publication statusPublished - 2001 May 7
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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