TY - JOUR
T1 - Advantages of histamine H4 receptor antagonist usage with H1 receptor antagonist for the treatment of murine allergic contact dermatitis
AU - Matsushita, Ayuko
AU - Seike, Masahiro
AU - Okawa, Haruka
AU - Kadawaki, Yayoi
AU - Ohtsu, Hiroshi
PY - 2012/9
Y1 - 2012/9
N2 - Histamine facilitates development of eczematous lesions in chronic allergic contact dermatitis. In addition to the well-known corticosteroid treatments, H1 receptor (H1R) antagonists also have been used. This study observed effects of histamine H4 receptor (H4R) antagonist usage with H1R antagonist in a murine chronic allergic contact dermatitis model, developed by repeated percutaneous challenge to the dorsal skin with 2,4,6-trinitro-1-chlorobenzene (TNCB). The H1R antagonist olopatadine hydrochloride and/or the H4R antagonist JNJ7777120 was then administered. Combination therapy was more effective than H1R antagonist monotherapy. Serum IgE and levels of interleukin (IL)-4, IL-5 and IL-6 (Th2 cytokines) in eczematous lesions decreased with combined therapy. Combined therapy with H1R and H4R antagonists counteracts the disadvantages of each as monotherapeutic agents and potentially represents a new strategy for the treatment of chronic allergic contact dermatitis.
AB - Histamine facilitates development of eczematous lesions in chronic allergic contact dermatitis. In addition to the well-known corticosteroid treatments, H1 receptor (H1R) antagonists also have been used. This study observed effects of histamine H4 receptor (H4R) antagonist usage with H1R antagonist in a murine chronic allergic contact dermatitis model, developed by repeated percutaneous challenge to the dorsal skin with 2,4,6-trinitro-1-chlorobenzene (TNCB). The H1R antagonist olopatadine hydrochloride and/or the H4R antagonist JNJ7777120 was then administered. Combination therapy was more effective than H1R antagonist monotherapy. Serum IgE and levels of interleukin (IL)-4, IL-5 and IL-6 (Th2 cytokines) in eczematous lesions decreased with combined therapy. Combined therapy with H1R and H4R antagonists counteracts the disadvantages of each as monotherapeutic agents and potentially represents a new strategy for the treatment of chronic allergic contact dermatitis.
KW - Chronic allergic contact dermatitis
KW - H1 receptor antagonist
KW - H4 receptor antagonist
UR - http://www.scopus.com/inward/record.url?scp=84865316898&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865316898&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0625.2012.01559.x
DO - 10.1111/j.1600-0625.2012.01559.x
M3 - Letter
C2 - 22897580
AN - SCOPUS:84865316898
VL - 21
SP - 714
EP - 715
JO - Experimental Dermatology
JF - Experimental Dermatology
SN - 0906-6705
IS - 9
ER -