To minimize the ecological burden originating in nuclear fuel recycling, a new R&D strategy, Adv.-ORIENT (Advanced Optimization by Recycling instructive Elemente) cycle, was set forth. In this context, mutual separation off-elements, such as minor actinide (MA)/lanthanide (Ln) and Am/Cm, are essential to enhance the MA (particularly 241Am) burning. Isotope separation before transmutation is inevitably required in the case of some long-lived fission products (LLFPs) like 126Sn, 133Cs, etc. The separation and utilization of rare metal fission products (RMFPs: Ru, Rh, Pd, Tc, Se, Te, etc.) can offer a new direction in the partitioning and transmutation (P&T) field. Separation of exothermic nuclides 90Sr, 137Cs as well as MA will significantly help to mitigate the repository tasks. A key separation tool is ion exchange chromatography (IXC) by a tertiary pyridine resin having soft donor nitrogen atoms. This method has provided individual recovery of pure Am and Cm products with a Pu/U/Np fraction from irradiated fuel in just a 3-step separation. A catalytic electrolytic extraction (CEE) method by Pdadatom has been employed to separate, purify and fabricate RMFP catalysts. High separation efficiency of RMFP proved hydrochloric acid as a suitable media for their recovery. Different functioned ion exchangers, e.g., ammonium molybdophosphate (AMP), have been investigated for the separation of Cs+. Theoretical and laboratory studies on the isotope separation of LLFPs were begun for 79Se, 126Sn and 135Cs.