TY - JOUR
T1 - Advanced Glycation End Products in Uremia
AU - Henle, Thomas
AU - Miyata, Toshio
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2003/10
Y1 - 2003/10
N2 - The term "advanced glycation end products" (AGEs) stands for a heterogenous group of amino acid derivatives that are formed via glycation processes between peptide-bound lysine or arginine derivatives and carbonyl compounds, processes originally known from food systems as "Maillard reactions." AGEs accumulate in plasma and tissues with advancing age, diabetes, and particular renal failure. In vivo and in vitro studies indicate that AGEs represent an important class of uremic toxins. This review focuses on the chemistry behind the formation of AGEs, possible mechanisms underlying the accumulation of AGEs in uremia, clinical and therapeutic implications, and possible nutritional consequences.
AB - The term "advanced glycation end products" (AGEs) stands for a heterogenous group of amino acid derivatives that are formed via glycation processes between peptide-bound lysine or arginine derivatives and carbonyl compounds, processes originally known from food systems as "Maillard reactions." AGEs accumulate in plasma and tissues with advancing age, diabetes, and particular renal failure. In vivo and in vitro studies indicate that AGEs represent an important class of uremic toxins. This review focuses on the chemistry behind the formation of AGEs, possible mechanisms underlying the accumulation of AGEs in uremia, clinical and therapeutic implications, and possible nutritional consequences.
KW - Advanced glycation end products
KW - Uremia
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U2 - 10.1053/j.arrt.2003.08.006
DO - 10.1053/j.arrt.2003.08.006
M3 - Article
C2 - 14681861
AN - SCOPUS:0348048493
VL - 10
SP - 321
EP - 331
JO - Advances in Chronic Kidney Disease
JF - Advances in Chronic Kidney Disease
SN - 1548-5595
IS - 4
ER -