Advanced glycation end products co-localized with astrocytes and microglial cells in Alzheimer's disease brain

Akinori Takeda, Takeshi Yasuda, Toshio Miyata, Yoji Goto, Masakazu Wakai, Masaki Watanabe, Yoshinari Yasuda, Katsunori Horie, Toshiaki Inagaki, Manabu Doyu, Kenji Maeda, Gen Sobue

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52 Citations (Scopus)

Abstract

In the previous study, we reported that the advanced glycation end products (AGEs) in the external space of neuronal perikarya (extraneuroperikaryal AGE deposits) were significantly abundant in the Alzheimer's brain. In this study, we investigated the spatial relationship of the extraneuroperikaryal AGE (carbocymethyllysine and pentosidine) deposits in astrocytes and microglial cells in the Alzheimer's disease brain using double immunolabelling for AGEs and astrocyte or microglial cell markers. Most of the extraneuroperikaryal AGE deposits were co-localized with glial fibrillary acidic protein-positive astrocytes. AGE deposit-bearing astrocytes also contained Gomori-positive granules. Furthermore, some of the extraneuroperikaryal AGE deposits were co-localized with microglial cells. These extraneuroperikaryal AGEs may activate astrocyte and microglia, and play a role in pathogenesis of Alzheimer's disease.

Original languageEnglish
Pages (from-to)555-558
Number of pages4
JournalActa neuropathologica
Volume95
Issue number6
DOIs
Publication statusPublished - 1998

Keywords

  • Advanced glycation end products
  • Alzheimer's disease
  • Astrocytes
  • Microglia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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    Takeda, A., Yasuda, T., Miyata, T., Goto, Y., Wakai, M., Watanabe, M., Yasuda, Y., Horie, K., Inagaki, T., Doyu, M., Maeda, K., & Sobue, G. (1998). Advanced glycation end products co-localized with astrocytes and microglial cells in Alzheimer's disease brain. Acta neuropathologica, 95(6), 555-558. https://doi.org/10.1007/s004010050839