Advanced glycation end-products, anti-hypertensive treatment and diastolic function in patients with hypertension and diastolic dysfunction

Jasper W.L. Hartog, Ruud M. Van De Wal, Casper G. Schalkwijk, Toshio Miyata, Wybren Jaarsma, H. W.Thijs Plokker, Leen M. Van Wijk, Andries J. Smit, Dirk J. Van Veldhuisen, Adriaan A. Voors

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

AimsTo investigate the relationship between advanced glycation end-products (AGEs) and diastolic function and the response to blood pressure treatment in patients with hypertension and diastolic dysfunction.Methods and resultsData were analysed from 97 patients (aged 65 ± 10 years, 36 male) who were randomly assigned to 6 months open-label treatment with either eprosartan on top of other anti-hypertensive drugs (n = 47) or other anti-hypertensive drugs alone (n = 50). Tissue AGE accumulation was measured using a validated skin-autofluorescence (skin-AF) reader (n = 26). Plasma N ε- (carboxymethyl)lysine (CML), N ε-(carboxyethyl)lysine (CEL), and pentosidine were measured by LC-MS/MS and HPLC. Diastolic function was assessed using echocardiography. Blood pressure was reduced from 157/91 to 145/84 mmHg (P < 0.001) in the eprosartan group and from 158/91 to 141/83 mmHg (P < 0.001) in the control group. No effect of eprosartan was found on AGE levels. In patients with baseline skin-AF < median, E/A ratio (P = 0.04) and the mean peak early-diastolic filling velocity (E′) improved (P = 0.001). In contrast, in patients with skin-AF levels > median, E/A ratio (P = 0.84) and mean E′ (P = 0.32) remained unchanged.ConclusionAlthough eprosartan did not decrease levels of AGEs, patients with lower skin-AF at baseline showed a larger improvement in diastolic function in response to either anti-hypertensive treatment compared with patients with higher skin-AF.

Original languageEnglish
Pages (from-to)397-403
Number of pages7
JournalEuropean Journal of Heart Failure
Volume12
Issue number4
DOIs
Publication statusPublished - 2010 Apr

Keywords

  • Advanced glycation end-products
  • Diastolic function
  • Hypertension
  • Skin-autofluorescence
  • Tissue velocity imaging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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