Advanced glycation end products (AGE) and their receptor (RAGE) in the brain of patients with Creutzfeldt-Jakob disease with prion plaques

Nobuyuki Sasaki, Masayoshi Takeuchi, Hiroshi Chowei, Seiji Kikuchi, Yorihide Hayashi, Norihito Nakano, Hiroshi Ikeda, Sho ichi Yamagishi, Tetsuyuki Kitamoto, Toshikazu Saito, Zenji Makita

Research output: Contribution to journalArticlepeer-review

96 Citations (Scopus)

Abstract

The objective of this study was to assess the pathological role of advanced glycation end products (AGE) and the receptor for AGE (RAGE) in Creutzfeldt-Jakob disease (CJD). We immunohistochemically investigated the occipital lobe of three patients with CJD containing with prion protein (PrP) plaques using anti-AGE and RAGE antibodies. Many PrP-positive plaques were observed in these patients, and the PrP-positive prion plaques also showed immunoreactivity for the anti-AGE antibody. Furthermore, many astrocytes contained-PrP positive granules, and the same astrocytes also contained many AGE- and RAGE-immunopositive granules. The staining pattern of these granules showed good concordance with that of PrP. These findings suggest that there may be a RAGE-mediated PrP degradation pathway in CJD as is the case for β-amyloid protein in Alzheimer's disease.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalNeuroscience Letters
Volume326
Issue number2
DOIs
Publication statusPublished - 2002 Jun 28

Keywords

  • Advanced glycation end products
  • Alzheimer's disease
  • Astrocyte
  • Creutzfeldt-Jakob disease
  • Prion protein
  • Receptor for advanced glycation end products

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Advanced glycation end products (AGE) and their receptor (RAGE) in the brain of patients with Creutzfeldt-Jakob disease with prion plaques'. Together they form a unique fingerprint.

Cite this