Advanced glycation and lipoxidation end products: Reactive carbonyl compounds-related uraemic toxicity

Toshio Miyata, Akira Saito, Kiyoshi Kurokawa, Charles Van Ypersele De Strihou

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Most studies on uraemic toxins have focused on disorders of enzymatic biochemistry. Recent studies to elucidate the pathogenesis of dialysis-related amyloidosis have provided new insights in progressive, irreversible protein modifications resulting from non-enzymatic biochemistry in uraemia. This paper focuses on two types of irreversible alterations of proteins: advanced glycation and lipoxidation. We investigate the causal role of various reactive carbonyl compounds (RCOs) accumulating in the serum, speculate on its clinical consequences, and discuss the therapeutic perspectives.

Original languageEnglish
Pages (from-to)8-11
Number of pages4
JournalNephrology Dialysis Transplantation
Volume16
Issue numberSUPPL. 4
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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