@inproceedings{7ac0990da55244ef923f07acf3093e5b,
title = "Advanced cavitation induction for improved reproducibility and in situ monitoring of sonodynamic cancer treatment",
abstract = "We developed a method for in situ monitoring of sonodynamic cancer treatment. When we used a protocol composed of ultrasound exposure at an acoustic intensity of several hundreds of W/cm 2 for a few seconds prior to exposure at an intensity of several tens of W/cm 2 for 60 s, the generation of bubbles that caused cavitation were observed as brightness changes in ultrasound images. These brightness changes could be observed not only in in vitro experiments using a 10% Ethanol solution but also in in vivo experiments using tumor-bearing mice. The results suggest that as the brightness changes persisted for longer periods, the treatment had a severer effect.",
keywords = "Cancer treatment, Cavitation, In situ monitoring, Sonodynamic therapy",
author = "Nami Sugita and Kawabata, {Ken Ichi} and Takashi Azuma and Hideki Yoshikawa and Umemura, {Shin Ichiro}",
year = "2006",
month = may,
day = "8",
doi = "10.1063/1.2205536",
language = "English",
isbn = "073540321X",
series = "AIP Conference Proceedings",
pages = "558--562",
booktitle = "THERAPEUTIC ULTRASOUND",
note = "THERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound ; Conference date: 27-10-2005 Through 29-10-2005",
}
