Advanced cavitation induction for improved reproducibility and in situ monitoring of sonodynamic cancer treatment

Nami Sugita, Ken Ichi Kawabata, Takashi Azuma, Hideki Yoshikawa, Shin Ichiro Umemura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We developed a method for in situ monitoring of sonodynamic cancer treatment. When we used a protocol composed of ultrasound exposure at an acoustic intensity of several hundreds of W/cm 2 for a few seconds prior to exposure at an intensity of several tens of W/cm 2 for 60 s, the generation of bubbles that caused cavitation were observed as brightness changes in ultrasound images. These brightness changes could be observed not only in in vitro experiments using a 10% Ethanol solution but also in in vivo experiments using tumor-bearing mice. The results suggest that as the brightness changes persisted for longer periods, the treatment had a severer effect.

Original languageEnglish
Title of host publicationTHERAPEUTIC ULTRASOUND
Subtitle of host publication5th International Symposium on Therapeutic Ultrasound
Pages558-562
Number of pages5
DOIs
Publication statusPublished - 2006 May 8
EventTHERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound - Boston, MA, United States
Duration: 2005 Oct 272005 Oct 29

Publication series

NameAIP Conference Proceedings
Volume829
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

OtherTHERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound
CountryUnited States
CityBoston, MA
Period05/10/2705/10/29

Keywords

  • Cancer treatment
  • Cavitation
  • In situ monitoring
  • Sonodynamic therapy

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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