Adult t-cell leukemia derived from s100β positive double-negative (CD4- CD8-) t cells

Hitoshi Suzushima, Norio Asou, Toshio Hattori, Kiyoshi Takatsuki

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Adult T-cell leukemia (ATL) is a mature T-cell malignancy which is caused by human T lymphotropic virus type-I (HTLV-I). Most of the ATL cells are CD3+, CD4+, CD8-, and T-cell receptor (TCR) aβ+ and also express activated antigens such as HLA-DR and inter-leukin-2 receptor (IL2R) α chain (CD25). Diminished surface expression of the TCRαbeta;CD3 complex is a specific feature of ATL cells. Since the gene transcript for each chain of this complex has been detected and surface expression of this complex is further decreased, accompanied by the induction of IL2Ra chain, after stimulation with anti-CD3 monoclonal antibody (mAb), the TCRαbeta;CD3 complex is considered to be down-modulated in vivo. We recently reported four ATL patients whose leukemic cells were CD4-, CD8- (double-negative; DN), TCRαbeta;+. These DN-ATL cells expressed S100αbeta; protein which was not detected in CD4+ ATL cells. Similar to CD4+ ATL cells, surface expression of the TCRαbeta;CD3 complex on DN-ATL cells was decreased in vivo despite the lack of CD4 or CD8 as core-ceptor. Therefore, the TCRαbeta;+ T-cell with or without CD4 is the sole target of HTLV-I induced leukemia and the down-modulation of the TCRαbeta;CD3 complex is considered to play a key role in the development of ATL.

Original languageEnglish
Pages (from-to)257-262
Number of pages6
JournalLeukemia and Lymphoma
Volume13
Issue number3-4
DOIs
Publication statusPublished - 1994
Externally publishedYes

Keywords

  • Adult T-cell leukemia ATL
  • Double negative CD4 CD8
  • S-100β
  • T-cells

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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