Adult Onset of BRAFV600E-Mutated Langerhans Cell Histiocytosis with Cutaneous Involvement Successfully Diagnosed by Immunohistochemical Staining

Hisayuki Tono, Taku Fujimura, Aya Kakizaki, Sadanori Furudate, Masaya Ishibashi, Setsuya Aiba

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Langerhans cell histiocytosis (LCH) is characterized by the clonal proliferation of Langerhans cells; it is categorized as a single-system disease with single or multifocal lesions, and as a multi-system disease with or without the risk of organ involvement. Although the skin is not categorized as a risk organ, the precise diagnosis of skin lesions is necessary to determine the protocol for the treatment of LCH. In this report, we describe a 28-year-old Japanese man with adult onset of BRAFV600E-mutated LCH with cutaneous involvement successfully diagnosed by immunohistochemical staining. Our report suggests that immunohistochemical staining for the BRAFV600E gene could be a diagnostic tool to determine the clinical type of LCH.

Original languageEnglish
Pages (from-to)237-240
Number of pages4
JournalCase Reports in Dermatology
Volume7
Issue number3
DOIs
Publication statusPublished - 2015 Dec 1

Keywords

  • Adult onset of Langerhans cell histiocytosis
  • BRAF
  • Chemotherapy
  • Clinical type

ASJC Scopus subject areas

  • Dermatology

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