Adult onset Fanconi syndrome: Extensive tubulo-interstitial lesions and glomerulopathy in the early stage of Chinese herbs nephropathy

Itsuro Kazama, Mitsunobu Matsubara, Mari Michimata, Michiko Suzuki, Ryo Hatano, Hiroshi Sato, Sadayoshi Ito

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

A 33-year-old woman was transferred to our hospital with a 5-month history of taking Chinese herbal medicine containing aristolochic acid. She presented with metabolic acidosis, severe anemia, hypophosphatemia and uric aciduria, and generalized aminoaciduria and glycosuria, features which were consistent with the clinical manifestations of Fanconi syndrome. Renal biopsy was performed when her plasma creatinine was 0.7 mg/dl and creatinine clearance was 46 ml/ min per 1.73 m2. The renal specimen showed extensive interstitial edema with focal fibrosis, tubular atrophy, and focal glomerulopathy, which suggested the presence of glomerular endothelial damage or glomerular ischemia. Although steroid therapy ameliorated the plasma electrolyte levels, renal failure progressed, and hemodialysis therapy was initiated approximately 18 months after the time of renal biopsy. This patient demonstrated the early renal lesions of Chinese herbs nephropathy in association with various clinical manifestations. The characteristic glomerulopathy found in the present patient is considered to be an additional renal lesion, leading to the renal failure.

Original languageEnglish
Pages (from-to)283-287
Number of pages5
JournalClinical and experimental nephrology
Volume8
Issue number3
DOIs
Publication statusPublished - 2004 Sep

Keywords

  • Chinese herbs
  • Glomerulopathy
  • Interstitial nephropathy
  • Renal failure
  • Toxic nephropathy

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)

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