TY - CHAP
T1 - Adult epilepsy
AU - Jin, Kazutaka
AU - Nakasato, Nobukazu
N1 - Funding Information:
J S Duncan has been consulted by and received fees for lectures from Eisai, GE Healthcare, Pfizer, GlaxoSmithKline, SanofiAventis, and UCB; he has had departmental and grant support from MedTronic, Cyberonics, and VSM MedTech. J W Sander has been consulted by and received research grants and fees for lectures from Eisai, Pfizer, Sanofi-Aventis, UCB, and Schwartz Pharma; he has received fees for lectures from Novartis. S M Sisodiya has received fees for lectures or research grant support from Pfizer, GlaxoSmithKline, and UCB. M C Walker has been consulted by, received fees for lectures and research grants from UCB; he has received fees for lectures from Pfizer, has been consulted by Eisai, and has received research grant funding from Johnson & Johnson.
Publisher Copyright:
© Springer Japan 2016.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Both electroencephalography (EEG) and magnetoencephalography (MEG) measure the same underlying brain activities. The greatest advantage of MEG is that source estimation techniques are easier to apply for MEG than for EEG. Magnetic source imaging (MSI) of interictal spikes as part of presurgical evaluations is one of the most successful clinical applications of MEG. MSI provides additional information to conventional presurgical evaluations by other noninvasive modalities in some patients with intractable epilepsy, especially those with neocortical/extratemporal lobe epilepsy or epilepsy with normal magnetic resonance imaging (MRI). MSI is recommended for the following situations: (1) no clear hypothesis regarding ictal onset, (2) insular onset suspected, (3) interhemispheric onset (especially frontal) suspected, (4) mesial temporal onset suspected without clear evidence of hippocampal sclerosis on MRI, (5) intrasylvian onset suspected, (6) multiple or very large epileptogenic lesion on MRI, and (7) planned intracranial EEG (especially previous craniotomy including revision epilepsy surgery). MSI can provide guidance for additional electrode coverage for intracranial EEG and the extent of the resection area when planning surgery. A single tight cluster of MEG spike dipoles is well correlated with ictal onset zone. Complete resection of the MEG focus often results in seizure freedom after surgery.
AB - Both electroencephalography (EEG) and magnetoencephalography (MEG) measure the same underlying brain activities. The greatest advantage of MEG is that source estimation techniques are easier to apply for MEG than for EEG. Magnetic source imaging (MSI) of interictal spikes as part of presurgical evaluations is one of the most successful clinical applications of MEG. MSI provides additional information to conventional presurgical evaluations by other noninvasive modalities in some patients with intractable epilepsy, especially those with neocortical/extratemporal lobe epilepsy or epilepsy with normal magnetic resonance imaging (MRI). MSI is recommended for the following situations: (1) no clear hypothesis regarding ictal onset, (2) insular onset suspected, (3) interhemispheric onset (especially frontal) suspected, (4) mesial temporal onset suspected without clear evidence of hippocampal sclerosis on MRI, (5) intrasylvian onset suspected, (6) multiple or very large epileptogenic lesion on MRI, and (7) planned intracranial EEG (especially previous craniotomy including revision epilepsy surgery). MSI can provide guidance for additional electrode coverage for intracranial EEG and the extent of the resection area when planning surgery. A single tight cluster of MEG spike dipoles is well correlated with ictal onset zone. Complete resection of the MEG focus often results in seizure freedom after surgery.
KW - Extratemporal lobe epilepsy
KW - Magnetic source imaging
KW - Presurgical evaluation
KW - Temporal lobe epilepsy
UR - http://www.scopus.com/inward/record.url?scp=84978224657&partnerID=8YFLogxK
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U2 - 10.1007/978-4-431-55729-6_10
DO - 10.1007/978-4-431-55729-6_10
M3 - Chapter
AN - SCOPUS:84978224657
SN - 9784431557289
SP - 175
EP - 185
BT - Clinical Applications of Magnetoencephalography
PB - Springer Japan
ER -