@article{5df195ace13141c3827eee8484701915,
title = "Adrenomedullin is a novel adipokine: Adrenomedullin in adipocytes and adipose tissues",
abstract = "Adrenomedullin (AM) is a multifunctional regulatory peptide that is produced and secreted by various types of cells. The production and the secretion of AM have been demonstrated in cultured adipocytes and adipose tissues. Inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and lipopolysaccharide are strong stimulators for AM expression in adipocytes. Furthermore, AM expression in the adipose tissue is increased in obesity, and plasma concentrations of AM are increased in obese subjects. One possible (patho)physiological role of AM secreted by adipose tissue may be actions against complications of the metabolic syndrome characterized by obesity, type 2 diabetic mellitus and hypertension, via its antioxidant and potent vasodilator effects. These findings indicate that AM is a new member of the adipokine family.",
keywords = "Adipocytes, Adipokine, Adrenomedullin, Metabolic syndrome",
author = "Yin Li and Changtao Jiang and Xian Wang and Yan Zhang and Shigeki Shibahara and Kazuhiro Takahashi",
note = "Funding Information: This work was supported partly by the China Postdoctoral Science Foundation (to Y.L., No. 2005038038), the Major National Basic Research Program of PR China (to X.W., No. 2006CB503802), the grant from the National Natural Science Foundation of PR China (to X.W., No. 30330250), the Program for Innovative Research Teams in Universities (to X.W.), the 21st COE programs {\textquoteleft}Center for Innovative Therapeutic Development towards the Conquest of Signal Transduction Diseases{\textquoteright} (to Y.L., Y.Z., S.S.), and {\textquoteleft}Comprehensive Research and Education Center for Drug Development and Clinical Evaluation (CRESCENDO){\textquoteright} (to K.T.), by a Grant-in-aid for Scientific Research (C) from the Ministry of Education, Science, Sports and Culture of Japan (to K.T.), and Research Grants (to K.T.) from the HIROMI Medical Research Foundation (2001), the Intelligent Cosmos Academic Foundation (2002, 2003) and the Takeda Research Foundation (2005).",
year = "2007",
month = may,
doi = "10.1016/j.peptides.2007.03.005",
language = "English",
volume = "28",
pages = "1129--1143",
journal = "Peptides",
issn = "0196-9781",
publisher = "Elsevier Inc.",
number = "5",
}