Adrenomedullin is a novel adipokine: Adrenomedullin in adipocytes and adipose tissues

Yin Li; Changtao Jiang; Xian Wang; Yan Zhang; Shigeki Shibahara; Kazuhiro Takahashi

doi:10.1016/j.peptides.2007.03.005

Adrenomedullin is a novel adipokine: Adrenomedullin in adipocytes and adipose tissues

Yin Li, Changtao Jiang, Xian Wang, Yan Zhang, Shigeki Shibahara, Kazuhiro Takahashi

Research output: Contribution to journal › Review article › peer-review

52 Citations (Scopus)

Abstract

Adrenomedullin (AM) is a multifunctional regulatory peptide that is produced and secreted by various types of cells. The production and the secretion of AM have been demonstrated in cultured adipocytes and adipose tissues. Inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and lipopolysaccharide are strong stimulators for AM expression in adipocytes. Furthermore, AM expression in the adipose tissue is increased in obesity, and plasma concentrations of AM are increased in obese subjects. One possible (patho)physiological role of AM secreted by adipose tissue may be actions against complications of the metabolic syndrome characterized by obesity, type 2 diabetic mellitus and hypertension, via its antioxidant and potent vasodilator effects. These findings indicate that AM is a new member of the adipokine family.

Original language	English
Pages (from-to)	1129-1143
Number of pages	15
Journal	Peptides
Volume	28
Issue number	5
DOIs	https://doi.org/10.1016/j.peptides.2007.03.005
Publication status	Published - 2007 May

Keywords

Adipocytes
Adipokine
Adrenomedullin
Metabolic syndrome

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.peptides.2007.03.005

Cite this

@article{5df195ace13141c3827eee8484701915,

title = "Adrenomedullin is a novel adipokine: Adrenomedullin in adipocytes and adipose tissues",

abstract = "Adrenomedullin (AM) is a multifunctional regulatory peptide that is produced and secreted by various types of cells. The production and the secretion of AM have been demonstrated in cultured adipocytes and adipose tissues. Inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and lipopolysaccharide are strong stimulators for AM expression in adipocytes. Furthermore, AM expression in the adipose tissue is increased in obesity, and plasma concentrations of AM are increased in obese subjects. One possible (patho)physiological role of AM secreted by adipose tissue may be actions against complications of the metabolic syndrome characterized by obesity, type 2 diabetic mellitus and hypertension, via its antioxidant and potent vasodilator effects. These findings indicate that AM is a new member of the adipokine family.",

keywords = "Adipocytes, Adipokine, Adrenomedullin, Metabolic syndrome",

author = "Yin Li and Changtao Jiang and Xian Wang and Yan Zhang and Shigeki Shibahara and Kazuhiro Takahashi",

note = "Funding Information: This work was supported partly by the China Postdoctoral Science Foundation (to Y.L., No. 2005038038), the Major National Basic Research Program of PR China (to X.W., No. 2006CB503802), the grant from the National Natural Science Foundation of PR China (to X.W., No. 30330250), the Program for Innovative Research Teams in Universities (to X.W.), the 21st COE programs {\textquoteleft}Center for Innovative Therapeutic Development towards the Conquest of Signal Transduction Diseases{\textquoteright} (to Y.L., Y.Z., S.S.), and {\textquoteleft}Comprehensive Research and Education Center for Drug Development and Clinical Evaluation (CRESCENDO){\textquoteright} (to K.T.), by a Grant-in-aid for Scientific Research (C) from the Ministry of Education, Science, Sports and Culture of Japan (to K.T.), and Research Grants (to K.T.) from the HIROMI Medical Research Foundation (2001), the Intelligent Cosmos Academic Foundation (2002, 2003) and the Takeda Research Foundation (2005).",

year = "2007",

month = may,

doi = "10.1016/j.peptides.2007.03.005",

language = "English",

volume = "28",

pages = "1129--1143",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Inc.",

number = "5",

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TY - JOUR

T1 - Adrenomedullin is a novel adipokine

T2 - Adrenomedullin in adipocytes and adipose tissues

AU - Li, Yin

AU - Jiang, Changtao

AU - Wang, Xian

AU - Zhang, Yan

AU - Shibahara, Shigeki

AU - Takahashi, Kazuhiro

N1 - Funding Information: This work was supported partly by the China Postdoctoral Science Foundation (to Y.L., No. 2005038038), the Major National Basic Research Program of PR China (to X.W., No. 2006CB503802), the grant from the National Natural Science Foundation of PR China (to X.W., No. 30330250), the Program for Innovative Research Teams in Universities (to X.W.), the 21st COE programs ‘Center for Innovative Therapeutic Development towards the Conquest of Signal Transduction Diseases’ (to Y.L., Y.Z., S.S.), and ‘Comprehensive Research and Education Center for Drug Development and Clinical Evaluation (CRESCENDO)’ (to K.T.), by a Grant-in-aid for Scientific Research (C) from the Ministry of Education, Science, Sports and Culture of Japan (to K.T.), and Research Grants (to K.T.) from the HIROMI Medical Research Foundation (2001), the Intelligent Cosmos Academic Foundation (2002, 2003) and the Takeda Research Foundation (2005).

PY - 2007/5

Y1 - 2007/5

N2 - Adrenomedullin (AM) is a multifunctional regulatory peptide that is produced and secreted by various types of cells. The production and the secretion of AM have been demonstrated in cultured adipocytes and adipose tissues. Inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and lipopolysaccharide are strong stimulators for AM expression in adipocytes. Furthermore, AM expression in the adipose tissue is increased in obesity, and plasma concentrations of AM are increased in obese subjects. One possible (patho)physiological role of AM secreted by adipose tissue may be actions against complications of the metabolic syndrome characterized by obesity, type 2 diabetic mellitus and hypertension, via its antioxidant and potent vasodilator effects. These findings indicate that AM is a new member of the adipokine family.

AB - Adrenomedullin (AM) is a multifunctional regulatory peptide that is produced and secreted by various types of cells. The production and the secretion of AM have been demonstrated in cultured adipocytes and adipose tissues. Inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and lipopolysaccharide are strong stimulators for AM expression in adipocytes. Furthermore, AM expression in the adipose tissue is increased in obesity, and plasma concentrations of AM are increased in obese subjects. One possible (patho)physiological role of AM secreted by adipose tissue may be actions against complications of the metabolic syndrome characterized by obesity, type 2 diabetic mellitus and hypertension, via its antioxidant and potent vasodilator effects. These findings indicate that AM is a new member of the adipokine family.

KW - Adipocytes

KW - Adipokine

KW - Adrenomedullin

KW - Metabolic syndrome

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Adrenomedullin is a novel adipokine: Adrenomedullin in adipocytes and adipose tissues

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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