Adrenomedullin in human brain, adrenal glands and tumor tissues of pheochromocytoma, ganglioneuroblastoma and neuroblastoma

Fumitoshi Satoh, Kazuhiro Takahashi, Osamu Murakami, Kazuhito Totsune, Masahiko Sone, Makoto Ohneda, Keishi Abe, Yukio Miura, Yutaka Hayashi, Hironobu Sasano, Toraichi Mouri

Research output: Contribution to journalArticlepeer-review

152 Citations (Scopus)

Abstract

Adrenomedullin is a potent vasodilator peptide that was isolated from human pheochromocytoma. But the presence of adrenomedullin in the brain has not been clarified. We studied the presence of adrenomedullin in the human brain obtained at autopsy from 6 subjects by radioimmunoassay, as well as in the human adrenal glands and tumor tissues of pheochromocytoma, ganglioneuroblastoma and neuroblastoma. Immunoreactive adrenomedullin was detected in every region of human brain examined (0.26 − 1.4 pmol/g wet weight) with the highest concentrations found in thalamus (1.40 ± 0.39 pmol/g wet weight, mean ± SEM) and hypothalamus (1.28 ± 0.48 pmol/g wet weight). Reverse phase high performance liquid chromatography showed that the immunoreactive adrenomedullin in the human brain was eluted in the position of synthetic human adrenomedullin 1–52. High concentrations of immunoreactive adrenomedullin were found in human adrenal glands (12.6 ± 1.0 pmol/g wet weight, n = 7), pheochromocytoma (4.5 ± 1.5 pmol/g wet weight, n = 11), ganglioneuroblastoma (2.0 ± 1.3 pmol/g wet weight, n = 4) and neuroblastoma (0.55 ± 0.21 pmol/g wet weight, n = 3). The present study has shown that adrenomedullin is present in the human brain in high concentrations, suggesting that adrenomedullin acts as a neurotransmitter, neuromodulator or neurohormone in man.

Original languageEnglish
Pages (from-to)1750-1752
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume80
Issue number5
DOIs
Publication statusPublished - 1995 Jan 1

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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