TY - JOUR
T1 - Adrenocortical peptides
T2 - Autocrine or paracrine regulators for the steroid hormone secretion or the cell proliferation?
AU - Takahashi, Kazuhiro
AU - Totsune, Kazuhito
AU - Murakami, O.
PY - 2002/11/1
Y1 - 2002/11/1
N2 - There is accumulating evidence that indicates the production and secretion of some peptides by adrenal cortex and adreno-cortical tumors. These peptides include adrenomedullin, pro-adrenomedullin N-terminal 20 peptide (PAMP), endothelin-1, cerebellin, urotensin-II etc., and appear to be involved in the regulation of steroid hormone secretion and the proliferation of adrenocortical cells as autocrine and/or paracrine factors. It is noteworthy that expression of adrenomedullin is induced by hypoxia and inflammatory cytokines in various cells, raising the possibility that the adrenocortical production of adrenomedullin (and probably PAMP) may be increased in some inflammatory and/or ischemic conditions, and these two peptides may modulate the states of inflammatory and/or ischemic disorders. In addition to adrenomedullin and PAMP, adrenal cortex and/or some adrenocortical tumors express endothelin-1, cerebellin, urotensin-II, etc. The adrenocortical peptides may form a novel autocrine or paracrine regulatory system for the steroid hormone secretion and the cell proliferation in the adrenal cortex, and involve in the pathophysiology of inflammatory, ischemic or neoplastic diseases of the adrenal cortex.
AB - There is accumulating evidence that indicates the production and secretion of some peptides by adrenal cortex and adreno-cortical tumors. These peptides include adrenomedullin, pro-adrenomedullin N-terminal 20 peptide (PAMP), endothelin-1, cerebellin, urotensin-II etc., and appear to be involved in the regulation of steroid hormone secretion and the proliferation of adrenocortical cells as autocrine and/or paracrine factors. It is noteworthy that expression of adrenomedullin is induced by hypoxia and inflammatory cytokines in various cells, raising the possibility that the adrenocortical production of adrenomedullin (and probably PAMP) may be increased in some inflammatory and/or ischemic conditions, and these two peptides may modulate the states of inflammatory and/or ischemic disorders. In addition to adrenomedullin and PAMP, adrenal cortex and/or some adrenocortical tumors express endothelin-1, cerebellin, urotensin-II, etc. The adrenocortical peptides may form a novel autocrine or paracrine regulatory system for the steroid hormone secretion and the cell proliferation in the adrenal cortex, and involve in the pathophysiology of inflammatory, ischemic or neoplastic diseases of the adrenal cortex.
KW - Adrenal
KW - Adrenomedullin
KW - Cerebellin
KW - Endothelin
KW - Urotensin
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UR - http://www.scopus.com/inward/citedby.url?scp=0036869887&partnerID=8YFLogxK
U2 - 10.1055/s-2002-36423
DO - 10.1055/s-2002-36423
M3 - Review article
C2 - 12518246
AN - SCOPUS:0036869887
VL - 110
SP - 373
EP - 380
JO - Experimental and Clinical Endocrinology and Diabetes
JF - Experimental and Clinical Endocrinology and Diabetes
SN - 0947-7349
IS - 8
ER -