ADMP2 is essential for primitive blood and heart development in Xenopus

Gaku Kumano, Carin Ezal, William C. Smith

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

We describe here the cloning of a new member of the TGF-β family with similarity to the anti-dorsalizing morphogenetic proteins (ADMPs). This new gene, ADMP2, is expressed in a broad band of mesendoderm cells that appear to include the progenitors of the endoderm and the ventral mesoderm. Antisense morpholino oligonucleotide knockdown of ADMP2 results in near-complete disruption of primitive blood and heart development, while the development of other mesoderm derivatives, including pronephros, muscle and lateral plate is not disrupted. Moreover, the development of the primitive blood in ADMP2 knockdown embryos cannot be rescued by BMP. These results suggests that ADMP2 plays an early role in specifying presumptive ventral mesoderm in the leading edge mesoderm, and that ADMP2 activity may be necessary to respond to BMP signaling in the context of ventral mesoderm induction.

Original languageEnglish
Pages (from-to)411-423
Number of pages13
JournalDevelopmental Biology
Volume299
Issue number2
DOIs
Publication statusPublished - 2006 Nov 15

Keywords

  • Blood
  • Mesoderm
  • Xenopus

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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