Administration of standard-dose BEP regimen (bleomycin + etoposide + cisplatin) is essential for treatment of ovarian yolk sac tumour

Toyomi Satoh, Yoichi Aoki, Takahiro Kasamatsu, Kazunori Ochiai, Masashi Takano, Yoh Watanabe, Fumitaka Kikkawa, Nobuhiro Takeshima, Masayuki Hatae, Harushige Yokota, Toshiaki Saito, Nobuo Yaegashi, Hiroaki Kobayashi, Tsukasa Baba, Shoji Kodama, Tsuyoshi Saito, Noriaki Sakuragi, Toshiyuki Sumi, Toshiharu Kamura, Hiroyuki Yoshikawa

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Aim The aim of this study was to investigate prognostic factors, including postoperative chemotherapy regimen, for the treatment of ovarian yolk sac tumour (YST), and resulting fertility outcome. Methods A multi-institutional retrospective investigation was undertaken to identify patients with ovarian pure or mixed YST who were treated between 1980 and 2007. Postoperative chemotherapy regimen and other variables were assessed in univariate and multivariate analyses. Additionally, the reproductive safety of the BEP (bleomycin, etoposide and cisplatin) regimen was evaluated. Results There were 211 patients enrolled from 43 institutions. The BEP regimen and a non-BEP regimen were administered to 112 and 99 patients as postoperative chemotherapy, respectively. In univariate and multivariate analyses, age ≥ 22, alpha-fetoprotein ≥ 33,000 ng/ml, residual tumours after surgery and non-BEP regimen were independently and significantly associated with poor overall survival (OS). BEP was significantly superior to non-BEP in 5-year OS (93.6% versus 74.6%, P = 0.0004). Reduced-dose BEP (<75% standard-dose bleomycin and < 50% etoposide dose) was significantly associated with poorer 5-year OS compared with standard-dose BEP (89.4% versus 100%, P = 0.02 and 62.5% versus 96.9%, P = 0.0002). All patients who underwent fertility-sparing surgery recovered their menstrual cycles. Sixteen of 23 patients receiving BEP (70.0%) and 13 of 17 patients receiving non-BEP (76.5%) who were nulliparous at fertility-sparing surgery and married at the time of investigation gave birth to 21 and 19 healthy children, respectively. Conclusions The results of the present study suggest that standard-dose BEP should be administered for ovarian YST. BEP is as safe as non-BEP for preserving reproductive function.

Original languageEnglish
Pages (from-to)340-351
Number of pages12
JournalEuropean Journal of Cancer
Issue number3
Publication statusPublished - 2015 Feb


  • BEP regimen
  • Fertility
  • Ovarian yolk sac tumour
  • Prognosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Administration of standard-dose BEP regimen (bleomycin + etoposide + cisplatin) is essential for treatment of ovarian yolk sac tumour'. Together they form a unique fingerprint.

Cite this