Adiponectin suppresses tumorigenesis in ApcMin/+ mice

Kensuke Otani, Joji Kitayama, Koji Yasuda, Yasunori Nio, Masato Iwabu, Shinichi Okudaira, Junken Aoki, Toshimasa Yamauchi, Takashi Kadowaki, Hirokazu Nagawa

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Recent reports have shown that adiponectin has a suppressive effect on various types of malignancy. In order to clarify the role of adiponectin in colorectal carcinogenesis, we examined the effect of exogenous administration of adiponectin on intestinal polyp formation in C57BL/6 J-ApcMin/+ mice, which possess a point mutation in the Apc gene. And we found that adiponectin treatment significantly decreased the number of adenomatous polyps, especially polyps larger than 2 mm in diameter, in the small intestine. Two major receptors for adiponectin, AdipoR1 and AdipoR2, were expressed in adenomatous polyps, and their expression levels were not altered by adiponectin injection. In conclusion, adiponectin suppresses the growth of intestinal adenomas in the ApcMin/+ mice. Increasing the adiponectin level may be a new strategy for the prevention of colorectal cancer at an early step of carcinogenesis.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalCancer Letters
Volume288
Issue number2
DOIs
Publication statusPublished - 2010 Feb 28

Keywords

  • Adiponectin
  • Apc mice
  • Colorectal cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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