Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice

Yongyong Hou, Zhiyuan Liu, Zhuo Zuo, Tianchang Gao, Jingqi Fu, Huihui Wang, Yuanyuan Xu, Dianxin Liu, Masayuki Yamamoto, Beibei Zhu, Yiguo Zhang, Melvin E. Andersen, Qiang Zhang, Jingbo Pi

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

The maintenance of healthy adipose tissues is essential for efficient regulation of energy homeostasis. Nuclear factor-erythroid 2-related factor 1 (NFE2L1, also known as Nrf1), a CNC-bZIP protein, is a master regulator of the cellular adaptive response to stresses. To investigate the role of NFE2L1 in adipocytes, we bred a line of mice with adipocyte-specific Nfe2l1 knockout (Nfe2l1(f)-KO), and found that Nfe2l1(f)-KO mice exhibited a dramatically reduced subcutaneous adipose tissue (SAT) mass, insulin resistance, adipocyte hypertrophy, and severe adipose inflammation. Mechanistic studies revealed that Nfe2l1 deficiency may disturb the expression of lipolytic genes in adipocytes, leading to adipocyte hypertrophy followed by inflammation, pyroptosis, and insulin resistance. Our findings reveal a novel role for NFE2L1 in regulating adipose tissue plasticity and energy homeostasis.

Original languageEnglish
Pages (from-to)264-270
Number of pages7
JournalBiochemical and biophysical research communications
Volume503
Issue number1
DOIs
Publication statusPublished - 2018 Sep 3

Keywords

  • Adipose
  • Inflammation
  • Lipolysis
  • NFE2L1
  • Pyroptosis

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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