Adhesion effects of a guanidinium Ion appended dendritic "molecular glue" on the ATP-driven Sliding motion of actomyosin

Kou Okuro, Kazushi Kinbara, Kuniaki Takeda, Yuichi Inoue, Akihiko Ishijima, Takuzo Aida

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

A sticky end: A heterotropic conjugate of actin and myosin-actomysin-is stabilized by a water-soluble dendritic "molecular glue" bearing nine pendant guanidinium ions (see picture; ATP = adenosine triphosphate, ADP = adenosine diphosphate). The ATP-driven sliding motion of actin filaments on a myosinfunctionalized coverslip is decelerated or totally arrested with a higher-generation dendrimer, but not with a lower-generation one. (Figure Presented)

Original languageEnglish
Pages (from-to)3030-3033
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number17
DOIs
Publication statusPublished - 2010 Apr 12
Externally publishedYes

Keywords

  • Adhesion dendrimers molecular motion multivalent interactions
  • Proteins

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint

Dive into the research topics of 'Adhesion effects of a guanidinium Ion appended dendritic "molecular glue" on the ATP-driven Sliding motion of actomyosin'. Together they form a unique fingerprint.

Cite this