Adenosine, an identified active component from the driselase-treated fraction of rice bran, is effective at improving metabolic syndrome in stroke-prone spontaneously hypertensive rats

Ardiansyah, Hitoshi Shirakawa, Taku Shimeno, Takuya Koseki, Yoshihito Shiono, Tetsuya Murayama, Eiko Hatakeyama, Michio Komal

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

In the present study, we isolated and identified an active component from the Driselase-treated fraction and investigated its effect by acute and chronic oral administration on hypertension, lipid, and glucose metabolism in stroke-prone spontaneously hypertensive rats. The active component was identified as adenosine and improves hypertension after single oral administration. Rats who were 10 weeks old were divided into control and adenosine groups and were administered water or water with adenosine (10 mg/L), respectively, for 3 weeks. Hypertension and plasma lipid, nitric oxide, insulin, leptin, adiponectin levels, and glucose metabolism were significantly improved in the adenosine group. The mRNA expression levels of genes involved in lipid and glucose metabolism were altered in the adenosine group. Single oral administration of adenosine (10 mg/kg body weight) improved hypertension and plasma triglyceride, glucose, and nitric oxide levels 2 h after administration. In conclusion, oral acute and chronic administration of adenosine are beneficial and improve the metabolic syndrome-related disease parameters. & copy; 2009 American Chemical Society.

Original languageEnglish
Pages (from-to)2558-2564
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume57
Issue number6
DOIs
Publication statusPublished - 2009 Mar 25

Keywords

  • Adenosine
  • Glucose metabolism
  • Hepatic gene expression
  • Hypertension
  • Lipid profile
  • Rice bran

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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